MAP4K1 Antibody (PACO21916)
- SKU:
- PACO21916
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MAP4K1 Antibody (PACO21916) |
| Antibody SKU: | PACO21916 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from internal of human MEKKK 1. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from HepG2 cells, using MEKKK 1 antibody. |
| Background: | May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Beausoleil S.A., Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). |
| Synonyms: | Mitogen-activated protein kinase kinase kinase kinase 1; EC 2.7.11.1; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1 |
| UniProt Protein Function: | HPK1: a protein kinase of the STE20 family. Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine. May play a role in hematopoietic lineage decisions and growth regulation. Positively regulated by PGE2 and a negative regulator of PGE2-induced FOS gene transcription. Protein type: Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; STE group; STE20 family; KHS subfamilyChromosomal Location of Human Ortholog: 19q13.1-q13.4Cellular Component: cytoplasm; membraneMolecular Function: ATP binding; MAP kinase kinase kinase kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activityBiological Process: activation of JNK activity; activation of MAPKKK activity; cell proliferation; peptidyl-serine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; response to stress |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q92918 |
| NCBI GenInfo Identifier: | 29427916 |
| NCBI Gene ID: | 11184 |
| NCBI Accession: | Q92918.1 |
| UniProt Secondary Accession: | Q92918 |
| UniProt Related Accession: | Q92918 |
| Molecular Weight: | 90,425 Da |
| NCBI Full Name: | Mitogen-activated protein kinase kinase kinase kinase 1 |
| NCBI Synonym Full Names: | mitogen-activated protein kinase kinase kinase kinase 1 |
| NCBI Official Symbol: | MAP4K1 |
| NCBI Official Synonym Symbols: | HPK1 |
| NCBI Protein Information: | mitogen-activated protein kinase kinase kinase kinase 1 |
| UniProt Protein Name: | Mitogen-activated protein kinase kinase kinase kinase 1 |
| UniProt Synonym Protein Names: | Hematopoietic progenitor kinase; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1 |
| Protein Family: | Mitogen-activated protein kinase kinase kinase kinase |
| UniProt Gene Name: | MAP4K1 |
| UniProt Entry Name: | M4K1_HUMAN |
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