MAP3K6 Antibody (PACO21709)
- SKU:
- PACO21709
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MAP3K6 Antibody (PACO21709) |
| Antibody SKU: | PACO21709 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:50-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from internal of human MAP3K6. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using MAP3K6 antibody. |
| Background: | Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. Gregory S.G., Nature 441:315-321(2006). |
| Synonyms: | EC 2.7.11.25; M3K6; MAPKKK6; Mitogen-activated protein kinase kinase kinase 6; kinase MAP3K6 |
| UniProt Protein Function: | MEKK6: a member of the STE11 protein kinase family. Activates JNK, but not ERK or p38. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. Protein type: Protein kinase, STE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.25; STE group; STE11 familyChromosomal Location of Human Ortholog: 1p36.11Molecular Function: ATP binding; magnesium ion binding; MAP kinase kinase kinase activityBiological Process: activation of JNK activity; protein amino acid phosphorylation; signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| UniProt Code: | O95382 |
| NCBI GenInfo Identifier: | 262527573 |
| NCBI Gene ID: | 9064 |
| NCBI Accession: | O95382.3 |
| UniProt Secondary Accession: | O95382,Q59HF4, Q5SSD4, Q75PK3, Q96B75, A2ACE8, A2VDG4 A2VDG5 |
| UniProt Related Accession: | O95382, JE0363 |
| Molecular Weight: | 141,648 Da |
| NCBI Full Name: | Mitogen-activated protein kinase kinase kinase 6 |
| NCBI Synonym Full Names: | mitogen-activated protein kinase kinase kinase 6 |
| NCBI Official Symbol: | MAP3K6 |
| NCBI Official Synonym Symbols: | ASK2; MEKK6; MAPKKK6 |
| NCBI Protein Information: | mitogen-activated protein kinase kinase kinase 6 |
| UniProt Protein Name: | Mitogen-activated protein kinase kinase kinase 6 |
| UniProt Synonym Protein Names: | Apoptosis signal-regulating kinase 2 |
| Protein Family: | Mitogen-activated protein kinase kinase kinase |
| UniProt Gene Name: | MAP3K6 |
| UniProt Entry Name: | M3K6_HUMAN |
| Antibodies |
| MAP3K6 Antibody (PACO05678) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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