MAP3K21 Antibody (PACO59113)
- SKU:
- PACO59113
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MAP3K21 Antibody (PACO59113) |
| Antibody SKU: | PACO59113 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Mitogen-activated protein kinase kinase kinase 21 protein (640-794AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: 293T whole cell lysate, HepG2 whole cell lysate, Hela whole cell lysate. All lanes: MAP3K21 antibody at 3.3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 114, 64, 53 kDa. Observed band size: 114 kDa. |
| Background: | Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways. |
| Synonyms: | Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4), MAP3K21, KIAA1804 MLK4 |
| UniProt Protein Function: | MLK4: Activates the JUN N-terminal pathway. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protein kinase, TKL; Kinase, protein; Motility/polarity/chemotaxis; EC 2.7.11.25; Protein kinase, Ser/Thr (non-receptor); TKL group; MLK family; MLK subfamily Chromosomal Location of Human Ortholog: 1q42 Molecular Function:protein binding; protein homodimerization activity Biological Process: activation of JNK activity; protein amino acid autophosphorylation; protein amino acid phosphorylation |
| UniProt Code: | Q5TCX8 |
| NCBI GenInfo Identifier: | 71153820 |
| NCBI Gene ID: | 84451 |
| NCBI Accession: | Q5TCX8.1 |
| UniProt Secondary Accession: | Q5TCX8,Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1, B2RN34 |
| UniProt Related Accession: | Q5TCX8 |
| Molecular Weight: | 52,817 Da |
| NCBI Full Name: | Mitogen-activated protein kinase kinase kinase MLK4 |
| NCBI Official Symbol: | KIAA1804 |
| NCBI Official Synonym Symbols: | MLK4; dJ862P8.3 |
| NCBI Protein Information: | mitogen-activated protein kinase kinase kinase MLK4 |
| UniProt Protein Name: | Mitogen-activated protein kinase kinase kinase MLK4 |
| UniProt Synonym Protein Names: | Mixed lineage kinase 4 |
| Protein Family: | Mitogen-activated protein kinase kinase kinase |
| UniProt Gene Name: | MLK4 |
| UniProt Entry Name: | M3KL4_HUMAN |
| Antibodies | ELISA Kits |
| MLK4 Antibody (PACO01070) | MAP3KL4 Colorimetric Cell-Based ELISA |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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