Map3k1 Antibody (PACO33584)

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SKU:
PACO33584
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Map3k1 Antibody (PACO33584)
Antibody SKU:PACO33584
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Mouse
Immunogen:Recombinant Mouse Mitogen-activated protein kinase kinase kinase 1 protein (1216-1493AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.
Synonyms:Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1), Map3k1, Mekk Mekk1
UniProt Protein Function:MEKK1: a protein kinase of the STE11 family. Phosphorylates and activates MKK4 and -7, which in turn activate JNK1, -2 and -3. Contains 1 RING-type zinc finger. The RING finger domain of MEKK1 exhibits E3 ubiquitin ligase activity toward c-Jun. c-Jun is downregulated in response to osmotic stress via ubiquitination-mediated degradation by the RING finger domain of MEKK1. Overexpressed/overactivated in multiple tumor types. The Mek1/2 inhibitor U0126 blocks export of influenza viral particles and has been suggested as an antiviral treatment. Single mutations at the same point of each gene also associated with cardiofaciocutaneous syndrome, (also linked with Braf and Kras mutations), displaying morphological, cardiac and mental defects. Inhibitors: U0126, CI-1040/PD184352, PD-0325901 (Phase I cancer), ARRY-142886 (Phase 1, cancer).Protein type: Kinase, protein; EC 2.7.11.25; Protein kinase, STE; Ubiquitin conjugating system; Protein kinase, Ser/Thr (non-receptor); Ubiquitin ligase; Ligase; STE group; STE11 familyCellular Component: cell junction; cytoplasm; cytoskeleton; filamentous actin; membraneMolecular Function: cytoskeletal protein binding; JUN kinase binding; JUN kinase kinase kinase activity; MAP kinase kinase kinase activity; mitogen-activated protein kinase binding; mitogen-activated protein kinase kinase binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; sphingolipid binding; ubiquitin-protein ligase activityBiological Process: activation of JNK activity; apoptotic mitochondrial changes; camera-type eye development; JNK cascade; morphogenesis of an epithelial sheet; positive regulation of actin filament polymerization; regulation of cell migration; transforming growth factor beta receptor signaling pathway; wound healing
UniProt Protein Details:
NCBI Summary:
UniProt Code:P53349
NCBI GenInfo Identifier:19860665
NCBI Gene ID:26401
NCBI Accession:P53349.3
UniProt Secondary Accession:P53349,Q60831, Q9R0U3, Q9R256
UniProt Related Accession:P53349
Molecular Weight:161,289 Da
NCBI Full Name:Mitogen-activated protein kinase kinase kinase 1
NCBI Synonym Full Names:mitogen-activated protein kinase kinase kinase 1
NCBI Official Symbol:Map3k1  
NCBI Official Synonym Symbols:Mekk; MEKK1; MAPKKK1  
NCBI Protein Information:mitogen-activated protein kinase kinase kinase 1
UniProt Protein Name:Mitogen-activated protein kinase kinase kinase 1
UniProt Synonym Protein Names:MAPK/ERK kinase kinase 1; MEK kinase 1; MEKK 1
Protein Family:MAP3K12-binding inhibitory protein
UniProt Gene Name:Map3k1  
UniProt Entry Name:M3K1_MOUSE
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