MAJIN Antibody (PACO35910)
- SKU:
- PACO35910
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MAJIN Antibody (PACO35910) |
| Antibody SKU: | PACO35910 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Membrane-anchored junction protein (1-216AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO35910 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human spleen tissue using PACO35910 at dilution of 1:100. |
| Background: | Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane. |
| Synonyms: | Membrane-anchored junction protein, MAJIN, C11orf85 |
| UniProt Protein Function: | C11orf85: 2 isoforms of the human protein are produced by alternative splicingChromosomal Location of Human Ortholog: 11q13.1 |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q3KP22 |
| NCBI GenInfo Identifier: | 82524336 |
| NCBI Gene ID: | 283129 |
| NCBI Accession: | NP_001032302.1 |
| UniProt Secondary Accession: | Q3KP22 |
| UniProt Related Accession: | Q3KP22 |
| Molecular Weight: | 24,809 Da |
| NCBI Full Name: | uncharacterized protein C11orf85 isoform 1 |
| NCBI Synonym Full Names: | chromosome 11 open reading frame 85 |
| NCBI Official Symbol: | C11orf85 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | uncharacterized protein C11orf85 |
| UniProt Protein Name: | Uncharacterized protein C11orf85 |
| UniProt Synonym Protein Names: | |
| Protein Family: | |
| UniProt Gene Name: | C11orf85 |
| UniProt Entry Name: | CK085_HUMAN |
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