MAGEL2 Antibody (PACO19981)
- SKU:
- PACO19981
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MAGEL2 Antibody (PACO19981) |
| Antibody SKU: | PACO19981 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human MAGEL2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19981(MAGEL2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13 region. Affected individuals exhibit neonatal hypotonia, developmental delay, and childhood-onset obesity. Necdin (NDN), a gene involved in the terminal differentiation of neurons, localizes to this region of the genome and has been implicated as one of the genes responsible for the etiology of PWS. This gene is structurally similar to NDN, is also localized to the PWS chromosomal region, and is paternally imprinted, suggesting a possible role for it in PWS. |
| Synonyms: | MAGE-like 2 |
| UniProt Protein Function: | MAGE-L2: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Interacts with TRIM27Chromosomal Location of Human Ortholog: 15q11.2Cellular Component: retromer complex; early endosome; nucleus; endosomeMolecular Function: protein binding; ubiquitin-protein ligase activityBiological Process: transcription, DNA-dependent; rhythmic process; negative regulation of transcription, DNA-dependent; regulation of circadian rhythm; retrograde transport, endosome to GolgiDisease: Prader-willi Syndrome; Prader-willi-like Syndrome |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9UJ55 |
| NCBI GenInfo Identifier: | 17380152 |
| NCBI Gene ID: | |
| NCBI Accession: | Q9UJ55.1 |
| UniProt Secondary Accession: | Q9UJ55 |
| UniProt Related Accession: | Q9UJ55 |
| Molecular Weight: | 58,669 Da |
| NCBI Full Name: | MAGE-like protein 2 |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | |
| UniProt Protein Name: | MAGE-like protein 2 |
| UniProt Synonym Protein Names: | Necdin-like protein 1; Protein nM15 |
| Protein Family: | MAGE-like protein |
| UniProt Gene Name: | MAGEL2 |
| UniProt Entry Name: | MAGL2_HUMAN |
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