MAGEC2 Antibody (PACO19979)
- SKU:
- PACO19979
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MAGEC2 Antibody (PACO19979) |
| Antibody SKU: | PACO19979 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human MAGEC2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19979(MAGEC2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19979(MAGEC2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene is a member of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the other MAGEC genes are clustered on chromosome Xq26-q27. |
| Synonyms: | melanoma antigen family C, 2 |
| UniProt Protein Function: | MAGE-C2: Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex.Protein type: Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: Xq27Cellular Component: cytoplasm; nucleusMolecular Function: protein binding; ubiquitin protein ligase bindingBiological Process: cellular protein catabolic process; positive regulation of ubiquitin-protein ligase activity |
| UniProt Protein Details: | |
| NCBI Summary: | This gene is a member of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the other MAGEC genes are clustered on chromosome Xq26-q27. [provided by RefSeq, Oct 2009] |
| UniProt Code: | Q9UBF1 |
| NCBI GenInfo Identifier: | 7706605 |
| NCBI Gene ID: | 51438 |
| NCBI Accession: | NP_057333.1 |
| UniProt Secondary Accession: | Q9UBF1,Q5JZ00, Q96D45, Q9P1M6, Q9P1M7 |
| UniProt Related Accession: | Q9UBF1 |
| Molecular Weight: | 41,163 Da |
| NCBI Full Name: | melanoma-associated antigen C2 |
| NCBI Synonym Full Names: | MAGE family member C2 |
| NCBI Official Symbol: | MAGEC2 |
| NCBI Official Synonym Symbols: | CT10; HCA587; MAGEE1 |
| NCBI Protein Information: | melanoma-associated antigen C2 |
| UniProt Protein Name: | Melanoma-associated antigen C2 |
| UniProt Synonym Protein Names: | Cancer/testis antigen 10; CT10; Hepatocellular carcinoma-associated antigen 587; MAGE-C2 antigen; MAGE-E1 antigen |
| Protein Family: | Melanoma-associated antigen |
| UniProt Gene Name: | MAGEC2 |
| UniProt Entry Name: | MAGC2_HUMAN |
| Antibodies | ELISA Kits |
| MAGEC2 Antibody (PACO07101) | Human MAGEC2 (Melanoma-associated antigen C2) ELISA Kit (HUFI03542) |
| MAGEC2 Antibody (PACO10342) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
