MAFF Transcription Factor Activity Assay
- SKU:
- TFAB00204
- Product Type:
- ELISA Kit
- ELISA Type:
- Transcription Factor Assay
- Analytes:
- MAFF
- Reactivity:
- Human
- Reactivity:
- Mouse
Description
system_update_altDatasheet
| Product Name: | MAFF Transcription Factor Activity Assay |
| Product Code: | TFAB00204 |
| Target: | MAFF |
| Synonyms: | U-Maf, V-maf musculoaponeurotic fibrosarcoma oncogene homolog F |
| Reactivity: | Human, Mouse |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie MAFF transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | MAFF: Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition. Since it lacks a putative transactivation domain, it may behave as a transcriptional repressor when it dimerize among himself. May also serve as a transcriptional activator by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. May be involved in the cellular stress response. Belongs to the bZIP family. Maf subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: mitochondrion; nucleoplasm; nucleus Biological Process: blood coagulation; parturition; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter |
| NCBI Summary: | The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2009] |
| UniProt Code: | Q9ULX9 |
| NCBI GenInfo Identifier: | 21542145 |
| NCBI Gene ID: | 23764 |
| NCBI Accession: | Q9ULX9.2 |
| UniProt Secondary Accession: | Q9ULX9,Q9Y525, B4DV49, |
| UniProt Related Accession: | Q9ULX9 |
| Molecular Weight: | 14,569 Da |
| NCBI Full Name: | Transcription factor MafF |
| NCBI Synonym Full Names: | MAF bZIP transcription factor F |
| NCBI Official Symbol: | MAFF |
| NCBI Official Synonym Symbols: | U-MAF; hMafF |
| NCBI Protein Information: | transcription factor MafF |
| UniProt Protein Name: | Transcription factor MafF |
| UniProt Synonym Protein Names: | U-Maf; V-maf musculoaponeurotic fibrosarcoma oncogene homolog F |
| Protein Family: | MaFF-interacting protein |
| UniProt Gene Name: | MAFF |
| UniProt Entry Name: | MAFF_HUMAN |
