MAEL Antibody (PACO38994)
- SKU:
- PACO38994
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MAEL Antibody (PACO38994) |
| Antibody SKU: | PACO38994 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Protein maelstrom homolog protein (1-200AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO38994 at dilution of 1:100. |
 | Immunofluorescence staining of Hela cells with PACO38994 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage (By similarity). |
| Synonyms: | Protein maelstrom homolog, MAEL |
| UniProt Protein Function: | MAEL: Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuage. Belongs to the maelstrom family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: 1q24.1Cellular Component: XY body; autosome; perinuclear region of cytoplasm; cytoplasm; chromatin; nucleusMolecular Function: DNA bindingBiological Process: multicellular organismal development; DNA methylation during gametogenesis; cell morphogenesis; regulation of organ growth; negative regulation of transcription from RNA polymerase II promoter; male meiosis; fertilization; DNA damage response, signal transduction resulting in induction of apoptosis; synapsis; RNA-mediated gene silencing; gene expression; spermatogenesis; cell differentiation; negative regulation of apoptosis |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96JY0 |
| NCBI GenInfo Identifier: | 556503335 |
| NCBI Gene ID: | 84944 |
| NCBI Accession: | NP_001273307.1 |
| UniProt Secondary Accession: | Q96JY0,Q49AP9, Q5VZP8, Q9UIW6, B4DY43, E9JVC3 |
| UniProt Related Accession: | Q96JY0 |
| Molecular Weight: | 17,268 Da |
| NCBI Full Name: | protein maelstrom homolog isoform 3 |
| NCBI Synonym Full Names: | maelstrom spermatogenic transposon silencer |
| NCBI Official Symbol: | MAEL |
| NCBI Official Synonym Symbols: | CT128; SPATA35 |
| NCBI Protein Information: | protein maelstrom homolog; cancer/testis antigen 128; spermatogenesis associated 35 |
| UniProt Protein Name: | Protein maelstrom homolog |
| UniProt Synonym Protein Names: | |
| Protein Family: | Protein maelstrom |
| UniProt Gene Name: | MAEL |
| UniProt Entry Name: | MAEL_HUMAN |
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