MAEA Antibody (PACO00758)
- SKU:
- PACO00758
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MAEA Antibody |
| Antibody SKU: | PACO00758 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the Internal region of human Emp. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | MAEA; EMP; HLC10; PIG5; Macrophage erythroblast attacher; Cell proliferation-inducing gene 5 protein; Erythroblast macrophage protein; Human lung cancer oncogene 10 protein; HLC-10 |
| UniProt Protein Function: | MAEA: Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion; Actin-binding; Cell development/differentiation Chromosomal Location of Human Ortholog: 4p16.3 Cellular Component: contractile ring; cytoplasm; cytoskeleton; integral to plasma membrane; nuclear matrix; nucleus; spindle Molecular Function:actin binding Biological Process: cell adhesion; negative regulation of myeloid cell apoptosis |
| NCBI Summary: | This gene encodes a protein that mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. The encoded protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| UniProt Code: | Q7L5Y9 |
| NCBI GenInfo Identifier: | 74754297 |
| NCBI Gene ID: | 10296 |
| NCBI Accession: | Q7L5Y9.1 |
| UniProt Secondary Accession: | Q7L5Y9,O95285, Q5JB54, Q6ZRD6, Q9BQ11, Q9H9V6, Q9H9Z4 Q9NW84, |
| UniProt Related Accession: | Q7L5Y9 |
| Molecular Weight: | 26,802 Da |
| NCBI Full Name: | Macrophage erythroblast attacher |
| NCBI Synonym Full Names: | macrophage erythroblast attacher |
| NCBI Official Symbol: | MAEA |
| NCBI Official Synonym Symbols: | EMP; EMLP; GID9; PIG5; HLC-10 |
| NCBI Protein Information: | macrophage erythroblast attacher |
| UniProt Protein Name: | Macrophage erythroblast attacher |
| UniProt Synonym Protein Names: | Cell proliferation-inducing gene 5 protein; Erythroblast macrophage protein; Human lung cancer oncogene 10 protein; HLC-10 |
| Protein Family: | Macrophage erythroblast attacher |
| UniProt Gene Name: | MAEA |
| UniProt Entry Name: | MAEA_HUMAN |
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