MACROD1 Antibody (PACO40286)
- SKU:
- PACO40286
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MACROD1 Antibody (PACO40286) |
| Antibody SKU: | PACO40286 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human O-acetyl-ADP-ribose deacetylase MACROD1 protein (83-325AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO40286 at dilution of 1:100. |
| Background: | Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity. |
| Synonyms: | O-acetyl-ADP-ribose deacetylase MACROD1 (EC 3.2.2.-) (EC 3.5.1.-) (MACRO domain-containing protein 1) (Protein LRP16) ([Protein ADP-ribosylglutamate] hydrolase), MACROD1, LRP16 |
| UniProt Protein Function: | Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9BQ69 |
| NCBI GenInfo Identifier: | 13569840 |
| NCBI Gene ID: | 28992 |
| NCBI Accession: | NP_054786.2 |
| UniProt Secondary Accession: | Q9BQ69,Q9UH96 |
| UniProt Related Accession: | Q9BQ69 |
| Molecular Weight: | 35,505 Da |
| NCBI Full Name: | O-acetyl-ADP-ribose deacetylase MACROD1 |
| NCBI Synonym Full Names: | MACRO domain containing 1 |
| NCBI Official Symbol: | MACROD1 |
| NCBI Official Synonym Symbols: | LRP16 |
| NCBI Protein Information: | O-acetyl-ADP-ribose deacetylase MACROD1 |
| UniProt Protein Name: | O-acetyl-ADP-ribose deacetylase MACROD1 |
| UniProt Synonym Protein Names: | MACRO domain-containing protein 1; Protein LRP16; [Protein ADP-ribosylglutamate] hydrolase |
| Protein Family: | O-acetyl-ADP-ribose deacetylase |
| UniProt Gene Name: | MACROD1 |
| UniProt Entry Name: |
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