Name: LZTFL1 Antibody (PACO48158)
SKU: PACO48158
Availability: OutOfStock

Antibody Name:	LZTFL1 Antibody (PACO48158)
Antibody SKU:	PACO48158
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC, IF, IP
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200, IP:1:200-1:2000,
Species Reactivity:	Human
Immunogen:	Recombinant Human Leucine zipper transcription factor-like protein 1 protein (116-299AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Western Blot. Positive WB detected in: HEK293 whole cell lysate, HepG2 whole cell lysate, Hela whole cell lysate, U251 whole cell lysate. All lanes: LZTFL1 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 35, 33, 30 kDa. Observed band size: 35, 50 kDa..
	Immunofluorescent analysis of U251 cells using PACO48158 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
	Immunohistochemistry of paraffin-embedded human testis tissue using PACO48158 at dilution of 1:100.

Background:	Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
Synonyms:	Leucine zipper transcription factor-like protein 1, LZTFL1

UniProt Protein Function:	LZTFL1: Belongs to the LZTFL1 family.Chromosomal Location of Human Ortholog: 3p21.3Cellular Component: cytosolMolecular Function: identical protein binding; protein binding; protein complex bindingDisease: Bardet-biedl Syndrome 17
UniProt Protein Details:
NCBI Summary:	This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2013]
UniProt Code:	Q9NQ48
NCBI GenInfo Identifier:	74734310
NCBI Gene ID:	54585
NCBI Accession:	Q9NQ48.1
UniProt Secondary Accession:	Q9NQ48,Q8TC61, Q9NQ56, B3KSI9, B4E0K7
UniProt Related Accession:	Q9NQ48
Molecular Weight:	29,332 Da
NCBI Full Name:	Leucine zipper transcription factor-like protein 1
NCBI Synonym Full Names:	leucine zipper transcription factor like 1
NCBI Official Symbol:	LZTFL1
NCBI Official Synonym Symbols:	BBS17
NCBI Protein Information:	leucine zipper transcription factor-like protein 1
UniProt Protein Name:	Leucine zipper transcription factor-like protein 1
UniProt Synonym Protein Names:
Protein Family:	Leucine zipper transcription factor-like protein
UniProt Gene Name:	LZTFL1
UniProt Entry Name:	LZTL1_HUMAN