Antibody Name:	LXN Antibody (PACO14659)
Antibody SKU:	PACO14659
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Fusion protein of human LXN

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14659(LXN Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
	Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: A549 cells, Primary antibody: PACO14659(LXN Antibody) at dilution 1/667, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds.
	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14659(LXN Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).

Background:

Latexin, also designated endogenous carboxypeptidase inhibitor (ECI) or tissue carboxypeptidase inhibitor (TCI), belongs to the protease inhibitor I47 family of proteins. Latexin acts as a non-competitive, reversible inhibitor for metallocarboxypeptidases (MCPs), including CPA1, CPA2 and CPA4. It is a cytoplasmic protein that is highly expressed in heart, prostate, pancreas, ovary, kidney, brain and colon. Latexin consists of two topologically equivalent subdomains that bind to MCPs with low specificity, which gives it with the flexibility to inhibit all vertebrate A/B MCPs.

Synonyms:

latexin

UniProt Protein Function:	LXN: Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. Belongs to the protease inhibitor I47 (latexin) family.
UniProt Protein Details:	Chromosomal Location of Human Ortholog: 3q25.32 Molecular Function:protein binding
NCBI Summary:	This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. [provided by RefSeq, Oct 2008]
UniProt Code:	Q9BS40
NCBI GenInfo Identifier:	146345452
NCBI Gene ID:	56925
NCBI Accession:	Q9BS40.2
UniProt Secondary Accession:	Q9BS40,Q96PN2, Q9NQS6,
UniProt Related Accession:	Q9BS40
Molecular Weight:	25,750 Da
NCBI Full Name:	Latexin
NCBI Synonym Full Names:	latexin
NCBI Official Symbol:	LXN
NCBI Official Synonym Symbols:	ECI; TCI
NCBI Protein Information:	latexin
UniProt Protein Name:	Latexin
UniProt Synonym Protein Names:	Endogenous carboxypeptidase inhibitor; ECI; Protein MUM; Tissue carboxypeptidase inhibitor; TCI
Protein Family:	Latexin
UniProt Gene Name:	LXN
UniProt Entry Name:	LXN_HUMAN