LTN1 Antibody (PACO59940)
- SKU:
- PACO59940
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | LTN1 Antibody (PACO59940) |
| Antibody SKU: | PACO59940 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human E3 ubiquitin-protein ligase listerin protein (462-591AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO59940 diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | IHC image of PACO59940 diluted at 1:100 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity). |
| Synonyms: | E3 ubiquitin-protein ligase listerin (EC 2.3.2.27) (RING finger protein 160) (RING-type E3 ubiquitin transferase listerin) (Zinc finger protein 294), LTN1, C21orf10 C21orf98 KIAA0714 RNF160 ZNF294 |
| UniProt Protein Function: | ZNF294: a zinc-finger protein which contains one RING/zf-C3HC4 domain. The RING finger is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C. Many RING finger proteins play a key role in the ubiquitination pathway. A candidate colon cancer tumor suppressor genes identified using nonsense-mediated mRNA decay in colon cancer cells.Protein type: Ubiquitin ligase; Ligase; EC 6.3.2.-; Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 21q22.11Molecular Function: protein binding |
| UniProt Protein Details: | |
| NCBI Summary: | Like most RING finger proteins, LTN1 functions as an E3 ubiquitin ligase (Chu et al., 2009 [PubMed 19196968]).[supplied by OMIM, Nov 2010] |
| UniProt Code: | O94822 |
| NCBI GenInfo Identifier: | 313104324 |
| NCBI Gene ID: | 26046 |
| NCBI Accession: | O94822.6 |
| UniProt Secondary Accession: | O94822,Q05C47, Q9H8M4, Q9NUY5, Q9P0E9, A6NL41, A7E2D0 B2RTS0, C9J7U3, J3KPL4 |
| UniProt Related Accession: | O94822 |
| Molecular Weight: | 205,177 Da |
| NCBI Full Name: | E3 ubiquitin-protein ligase listerin |
| NCBI Synonym Full Names: | listerin E3 ubiquitin protein ligase 1 |
| NCBI Official Symbol: | LTN1 |
| NCBI Official Synonym Symbols: | RNF160; ZNF294; C21orf10; C21orf98 |
| NCBI Protein Information: | E3 ubiquitin-protein ligase listerin |
| UniProt Protein Name: | E3 ubiquitin-protein ligase listerin |
| UniProt Synonym Protein Names: | RING finger protein 160; Zinc finger protein 294 |
| Protein Family: | |
| UniProt Gene Name: | LTN1 |
| UniProt Entry Name: | LTN1_HUMAN |
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