Name: LTK Antibody (PACO55602)
SKU: PACO55602
Availability: OutOfStock

Antibody Name:	LTK Antibody (PACO55602)
Antibody SKU:	PACO55602
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, IF
Recommended Dilutions:	ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:	Human
Immunogen:	Recombinant Human Leukocyte tyrosine kinase receptor protein (20-175AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Immunofluorescence staining of HepG2 cells with PACO55602 at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Background:

Receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport.

Synonyms:

Leukocyte tyrosine kinase receptor (EC 2.7.10.1) (Protein tyrosine kinase 1), LTK, TYK1

UniProt Protein Function:	LTK: Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport. Homodimer when bound to ligand (Probable). Part a complex including LTK, TNK2 and GRB2, in which GRB2 promotes LTK recruitment by TNK2. Expressed in non-hematopoietic cell lines and T- and B-cell lines. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Membrane protein, integral; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Kinase, protein; Protein kinase, TK; TK group; Alk family Chromosomal Location of Human Ortholog: 15q15.1-q21.1 Cellular Component: integral to plasma membrane; membrane; plasma membrane Molecular Function:protein kinase activity; protein-tyrosine kinase activity Biological Process: cell proliferation; negative regulation of apoptosis; phosphoinositide 3-kinase cascade; protein amino acid phosphorylation; signal transduction
NCBI Summary:	The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
UniProt Code:	P29376
NCBI GenInfo Identifier:	143811416
NCBI Gene ID:	4058
NCBI Accession:	P29376.3
UniProt Secondary Accession:	P29376,A6NNJ8, B4DL89, E9PFX4,
UniProt Related Accession:	P29376
Molecular Weight:	78,714 Da
NCBI Full Name:	Leukocyte tyrosine kinase receptor
NCBI Synonym Full Names:	leukocyte receptor tyrosine kinase
NCBI Official Symbol:	LTK
NCBI Official Synonym Symbols:	TYK1
NCBI Protein Information:	leukocyte tyrosine kinase receptor
UniProt Protein Name:	Leukocyte tyrosine kinase receptor
UniProt Synonym Protein Names:	Protein tyrosine kinase 1
Protein Family:	Leukocyte tyrosine kinase receptor
UniProt Gene Name:	LTK
UniProt Entry Name:	LTK_HUMAN

Antibodies	ELISA Kits
LTK Antibody (PACO04255)	Human LTK / Leukocyte Receptor Tyrosine Kinase ELISA Kit
	Human Leukocyte tyrosine kinase receptor (LTK) ELISA Kit
	LTK Colorimetric Cell-Based ELISA

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)