LTK Antibody (PACO04255)

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SKU:
PACO04255
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Applications:
WB
Applications:
IHC
Applications:
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated

Description

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Antibody Name:LTK Antibody
Antibody SKU:PACO04255
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:Human, Mouse
Immunogen:synthesized peptide derived from the Internal region of human LTK.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:LTK; TYK1; Leukocyte tyrosine kinase receptor; Protein tyrosine kinase 1
UniProt Protein Function:LTK: Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport. Homodimer when bound to ligand (Probable). Part a complex including LTK, TNK2 and GRB2, in which GRB2 promotes LTK recruitment by TNK2. Expressed in non-hematopoietic cell lines and T- and B-cell lines. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Kinase, protein; Protein kinase, TK; TK group; Alk family

Chromosomal Location of Human Ortholog: 15q15.1-q21.1

Cellular Component: integral to plasma membrane; membrane; plasma membrane

Molecular Function:protein kinase activity; protein-tyrosine kinase activity

Biological Process: cell proliferation; negative regulation of apoptosis; phosphoinositide 3-kinase cascade; protein amino acid phosphorylation; signal transduction

NCBI Summary:The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
UniProt Code:P29376
NCBI GenInfo Identifier:143811416
NCBI Gene ID:4058
NCBI Accession:P29376.3
UniProt Secondary Accession:P29376,A6NNJ8, B4DL89, E9PFX4,
UniProt Related Accession:P29376
Molecular Weight:78,714 Da
NCBI Full Name:Leukocyte tyrosine kinase receptor
NCBI Synonym Full Names:leukocyte receptor tyrosine kinase
NCBI Official Symbol:LTK  
NCBI Official Synonym Symbols:TYK1  
NCBI Protein Information:leukocyte tyrosine kinase receptor
UniProt Protein Name:Leukocyte tyrosine kinase receptor
UniProt Synonym Protein Names:Protein tyrosine kinase 1
Protein Family:Leukocyte tyrosine kinase receptor
UniProt Gene Name:LTK  
UniProt Entry Name:LTK_HUMAN
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