Name: LTB Antibody (PACO23242)
SKU: PACO23242
Availability: OutOfStock

Antibody Name:	LTB Antibody (PACO23242)
Antibody SKU:	PACO23242
Size:	100ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IF
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:3000, IF:1:100-1:500
Species Reactivity:	Human, Mouse
Immunogen:	Synthesized peptide derived from C-terminal of human TNFC.

Form:	Liquid
Storage Buffer:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Western blot analysis of extracts from HepG2 cells, using TNFC antibody.
	Immunofluorescence analysis of HeLa cells, using TNFC antibody.

Background:	Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.
Synonyms:	Lymphotoxin-beta; LT-beta; Tumor necrosis factor C; TNF-C; Tumor necrosis factor ligand superfamily member 3

UniProt Protein Function:	LTB: Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: extracellular space; integral to membrane Molecular Function:cytokine activity; tumor necrosis factor receptor binding; receptor binding Biological Process: skin development; positive regulation of interleukin-12 biosynthetic process; cell-cell signaling; gene expression; immune response; signal transduction; lymph node development
NCBI Summary:	Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:	Q06643
NCBI GenInfo Identifier:	4505035
NCBI Gene ID:	4050
NCBI Accession:	NP_002332.1
UniProt Related Accession:	Q06643
Molecular Weight:	~ 25kDa
NCBI Full Name:	lymphotoxin-beta isoform a
NCBI Synonym Full Names:	lymphotoxin beta
NCBI Official Symbol:	LTB
NCBI Official Synonym Symbols:	p33; TNFC; TNFSF3; TNLG1C
NCBI Protein Information:	lymphotoxin-beta
UniProt Protein Name:	Lymphotoxin-beta
UniProt Synonym Protein Names:	Tumor necrosis factor C; TNF-C; Tumor necrosis factor ligand superfamily member 3
UniProt Gene Name:	LTB
UniProt Entry Name:	TNFC_HUMAN

Antibodies	ELISA Kits
LTB Antibody (PACO01032)	Human Lymphotoxin Beta ELISA Kit
LTB Antibody (PACO07384)	Human LT beta (Lymphotoxin Beta) CLIA Kit (HUES00945)
	Human Lymphotoxin-beta (LTB) ELISA Kit
	TNFC Colorimetric Cell-Based ELISA

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)