LSM6 Antibody (PACO28049)
- SKU:
- PACO28049
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | LSM6 Antibody (PACO28049) |
| Antibody SKU: | PACO28049 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human U6 snRNA-associated Sm-like protein LSm6 protein (1-80AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity). |
| Synonyms: | U6 snRNA-associated Sm-like protein LSm6, LSM6 |
| UniProt Protein Function: | LSM6: Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'- terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre- rRNAs and U3 snoRNA. Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.Protein type: Spliceosome; RNA processingChromosomal Location of Human Ortholog: 4q31.22Cellular Component: small nuclear ribonucleoprotein complex; spliceosome; small nucleolar ribonucleoprotein complex; U4/U6 x U5 tri-snRNP complex; nucleolus; cytosolMolecular Function: protein bindingBiological Process: nuclear mRNA splicing, via spliceosome; tRNA processing; RNA splicing; gene expression; mRNA catabolic process, deadenylation-dependent decay; maturation of SSU-rRNA |
| UniProt Protein Details: | |
| NCBI Summary: | Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004] |
| UniProt Code: | P62312 |
| NCBI GenInfo Identifier: | 5901998 |
| NCBI Gene ID: | 11157 |
| NCBI Accession: | NP_009011.1 |
| UniProt Secondary Accession: | P62312,Q4W5J5, Q9Y4Y8 |
| UniProt Related Accession: | P62312 |
| Molecular Weight: | 9,128 Da |
| NCBI Full Name: | U6 snRNA-associated Sm-like protein LSm6 |
| NCBI Synonym Full Names: | LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated |
| NCBI Official Symbol: | LSM6 |
| NCBI Official Synonym Symbols: | YDR378C |
| NCBI Protein Information: | U6 snRNA-associated Sm-like protein LSm6 |
| UniProt Protein Name: | U6 snRNA-associated Sm-like protein LSm6 |
| UniProt Synonym Protein Names: | |
| Protein Family: | U6 snRNA-associated Sm-like protein |
| UniProt Gene Name: | LSM6 |
| UniProt Entry Name: | LSM6_HUMAN |
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