Description
Antibody Name: | LRTOMT Antibody (PACO31268) |
Antibody SKU: | PACO31268 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Transmembrane O-methyltransferase protein (31-264AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunofluorescent analysis of HepG2 cells using PACO31268 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. |
Synonyms: | Transmembrane O-methyltransferase (EC 2.1.1.6) (Catechol O-methyltransferase 2) (Protein LRTOMT2), LRTOMT, COMT2 TOMT |
UniProt Protein Function: | LRTOMT: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Required for auditory function. Defects in LRTOMT are the cause of deafness autosomal recessive type 63 (DFNB63). A form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the methyltransferase superfamily. Catechol-O-methyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 2.1.1.6; Membrane protein, integral; Methyltransferase; Cell development/differentiationChromosomal Location of Human Ortholog: 11q13.4Molecular Function: catechol O-methyltransferase activityBiological Process: auditory receptor cell development; catecholamine catabolic process; sensory perception of soundDisease: Deafness, Autosomal Recessive 63 |
UniProt Protein Details: | |
NCBI Summary: | This gene includes two transcript forms. The short form has one open reading frame (ORF), which encodes the leucine-rich repeats (LRR)-containing protein of unknown function. This protein is called LRTOMT1 or LRRC51. The long form has two alternative ORFs; the upstream ORF has the same translation start codon as used in the short form and the resulting transcript is a candidate for nonsense-mediated decay, and the downstream ORF encodes a different protein, which is a transmembrane catechol-O-methyltransferase and is called LRTOMT2, TOMT or COMT2. The COMT2 is essential for auditory and vestibular function. Defects in the COMT2 can cause nonsyndromic deafness. Alternatively spliced transcript variants from each transcript form have been found for this gene. [provided by RefSeq, Sep 2012] |
UniProt Code: | Q8WZ04 |
NCBI GenInfo Identifier: | 226693615 |
NCBI Gene ID: | 220074 |
NCBI Accession: | Q8WZ04.3 |
UniProt Secondary Accession: | Q8WZ04,B7Z816 |
UniProt Related Accession: | Q8WZ04,Q96E66, Q8WZ04 |
Molecular Weight: | 27,548 Da |
NCBI Full Name: | Transmembrane O-methyltransferase |
NCBI Synonym Full Names: | leucine rich transmembrane and O-methyltransferase domain containing |
NCBI Official Symbol: | LRTOMT |
NCBI Official Synonym Symbols: | DFNB63; LRRC51; CFAP111 |
NCBI Protein Information: | leucine-rich repeat-containing protein 51; transmembrane O-methyltransferase |
UniProt Protein Name: | Transmembrane O-methyltransferase |
UniProt Synonym Protein Names: | Catechol O-methyltransferase 2 |
Protein Family: | |
UniProt Gene Name: | LRTOMT |
UniProt Entry Name: | TOMT_HUMAN |