LRRC45 Antibody (PACO58396)
- SKU:
- PACO58396
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | LRRC45 Antibody (PACO58396) |
| Antibody SKU: | PACO58396 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Leucine-rich repeat-containing protein 45 protein (222-357AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO58396 diluted at 1:400 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | Immunofluorescence staining of Hela cells with PACO58396 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | IHC image of PACO58396 diluted at 1:400 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion. |
| Synonyms: | Leucine-rich repeat-containing protein 45, LRRC45 |
| UniProt Protein Function: | ARF3: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Belongs to the small GTPase superfamily. Arf family.Protein type: G protein; G protein, monomeric; G protein, monomeric, ARF; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 12q13Cellular Component: Golgi membrane; perinuclear region of cytoplasmMolecular Function: GTPase activity; GTP bindingBiological Process: vesicle-mediated transport; protein transport; small GTPase mediated signal transduction; phospholipid metabolic process; phosphatidylinositol biosynthetic process |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96CN5 |
| NCBI GenInfo Identifier: | 33878373 |
| NCBI Gene ID: | 201255 |
| NCBI Accession: | BC014109 |
| UniProt Secondary Accession: | Q96CN5 |
| UniProt Related Accession: | Q96CN5 |
| Molecular Weight: | 75,951 Da |
| NCBI Full Name: | Homo sapiens leucine rich repeat containing 45, mRNA |
| NCBI Synonym Full Names: | leucine rich repeat containing 45 |
| NCBI Official Symbol: | LRRC45 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | leucine-rich repeat-containing protein 45 |
| UniProt Protein Name: | ADP-ribosylation factor 3 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Leucine-rich repeat-containing protein |
| UniProt Gene Name: | ARF3 |
| UniProt Entry Name: | ARF3_HUMAN |
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