LRRC15 Antibody (PACO16631)
- SKU:
- PACO16631
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | LRRC15 Antibody (PACO16631) |
| Antibody SKU: | PACO16631 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Fusion protein of human LRRC15 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO16631(LRRC15 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO16631(LRRC15 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | Leucine-rich repeats (LRRs) are 20-29 amino acid, motifs that mediate protein-protein interactions. The primary function of these motifs is to provide a versatile structural framework for the formation of these protein-protein interactions. LRRs are present in a variety of proteins with diverse structure and function, including innate immunity and nervous system development. Several human diseases are associated with mutations in genes encoding LRR-containing proteins. The leucine-rich repeat-containing protein 15 (LRRC15, also designated LIB) is a 581 amino acid, protein that contains 15 LRR repeats and is involved in cell-cell and/or -extracellular matrix interactions. LRRC15 is frequently overexpressed in multiple tumor types, most notably breast carcinoma. It is also associated with the pathogenesis of Alzheimers disease. |
| Synonyms: | leucine rich repeat containing 15 |
| UniProt Protein Function: | LRRC15: 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 3q29Cellular Component: integral to membraneMolecular Function: collagen binding; fibronectin binding; laminin bindingBiological Process: virion attachment, binding of host cell surface receptor; positive regulation of cell migration |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8TF66 |
| NCBI GenInfo Identifier: | 288541295 |
| NCBI Gene ID: | 131578 |
| NCBI Accession: | NP_001128529.2 |
| UniProt Secondary Accession: | Q8TF66,Q495Q6, Q7RTN7 |
| UniProt Related Accession: | Q8TF66 |
| Molecular Weight: | 64,366 Da |
| NCBI Full Name: | leucine-rich repeat-containing protein 15 isoform a |
| NCBI Synonym Full Names: | leucine rich repeat containing 15 |
| NCBI Official Symbol: | LRRC15 |
| NCBI Official Synonym Symbols: | LIB |
| NCBI Protein Information: | leucine-rich repeat-containing protein 15; hLib; leucine-rich repeat protein induced by beta amyloid; leucine-rich repeat protein induced by beta-amyloid homolog |
| UniProt Protein Name: | Leucine-rich repeat-containing protein 15 |
| UniProt Synonym Protein Names: | Leucine-rich repeat protein induced by beta-amyloid homolog; hLib |
| Protein Family: | Leucine-rich repeat-containing protein |
| UniProt Gene Name: | LRRC15 |
| UniProt Entry Name: | LRC15_HUMAN |
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