LRR1 Antibody (PACO46866)
- SKU:
- PACO46866
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | LRR1 Antibody (PACO46866) |
| Antibody SKU: | PACO46866 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Leucine-rich repeat protein 1 protein (18-159AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO46866 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO46866 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO46866 at dilution of 1:100. |
| Background: | May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
| Synonyms: | Leucine-rich repeat protein 1 (4-1BB-mediated-signaling molecule) (4-1BBlrr) (LRR-repeat protein 1) (LRR-1) (Peptidylprolyl isomerase-like 5), LRR1, PPIL5 |
| UniProt Protein Function: | PPIL5: May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 14q21.3Molecular Function: protein binding |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene contains a leucine-rich repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily. Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2), which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011] |
| UniProt Code: | Q96L50 |
| NCBI GenInfo Identifier: | 37079896 |
| NCBI Gene ID: | 122769 |
| NCBI Accession: | Q96L50.2 |
| UniProt Secondary Accession: | Q96L50,Q52M24, Q86SZ1, Q8N6H9, A5D6X3, B4DDE0 |
| UniProt Related Accession: | Q96L50 |
| Molecular Weight: | 16,964 Da |
| NCBI Full Name: | Leucine-rich repeat protein 1 |
| NCBI Synonym Full Names: | leucine rich repeat protein 1 |
| NCBI Official Symbol: | LRR1 |
| NCBI Official Synonym Symbols: | LRR-1; PPIL5; 4-1BBLRR |
| NCBI Protein Information: | leucine-rich repeat protein 1 |
| UniProt Protein Name: | Leucine-rich repeat protein 1 |
| UniProt Synonym Protein Names: | 4-1BB-mediated-signaling molecule; 4-1BBlrr; LRR-repeat protein 1; LRR-1; Peptidylprolyl isomerase-like 5 |
| Protein Family: | Leucine-rich repeat protein |
| UniProt Gene Name: | LRR1 |
| UniProt Entry Name: | LLR1_HUMAN |
| Antibodies | ELISA Kits |
| LRR1 Antibody (PACO11405) | Human LRR 1 (Leucine-rich repeat protein 1) ELISA Kit (HUFI03592) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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