LRR1 Antibody (PACO11405)
- SKU:
- PACO11405
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | LRR1 Antibody (PACO11405) |
| Antibody SKU: | PACO11405 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human PPIL5 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | peptidylprolyl isomerase (cyclophilin)-like 5;PPIL5;4-1BBLRR;LRR-1;MGC20689 ; |
| UniProt Protein Function: | PPIL5: May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 14q21.3Molecular Function: protein binding |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene contains a leucine-rich repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily. Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2), which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011] |
| UniProt Code: | Q96L50 |
| NCBI GenInfo Identifier: | 37079896 |
| NCBI Gene ID: | 122769 |
| NCBI Accession: | Q96L50.2 |
| UniProt Secondary Accession: | Q96L50,Q52M24, Q86SZ1, Q8N6H9, A5D6X3, B4DDE0 |
| UniProt Related Accession: | Q96L50 |
| Molecular Weight: | 16,964 Da |
| NCBI Full Name: | Leucine-rich repeat protein 1 |
| NCBI Synonym Full Names: | leucine rich repeat protein 1 |
| NCBI Official Symbol: | LRR1 |
| NCBI Official Synonym Symbols: | LRR-1; PPIL5; 4-1BBLRR |
| NCBI Protein Information: | leucine-rich repeat protein 1 |
| UniProt Protein Name: | Leucine-rich repeat protein 1 |
| UniProt Synonym Protein Names: | 4-1BB-mediated-signaling molecule; 4-1BBlrr; LRR-repeat protein 1; LRR-1; Peptidylprolyl isomerase-like 5 |
| Protein Family: | Leucine-rich repeat protein |
| UniProt Gene Name: | LRR1 |
| UniProt Entry Name: | LLR1_HUMAN |
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