LRP6 Monoclonal Antibody
- SKU:
- CAB22661
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | LRP6 Monoclonal Antibody |
| Product Code: | CAB22661 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC54062 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:1000-1:5000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa, Mouse lung, Rat colon |
| Cellular Location: | Endoplasmic reticulum, Membrane, Single-pass type I membrane protein |
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 900-1000 of human LRP6 (NP_002327.2). |
| Sequence: | CSHLC LAVPV GGFVC GCPAH YSLNA DNRTC SAPTT FLLFS QKSAI NRMVI DEQQS PDIIL PIHSL RNVRA IDYDP LDKQL YWIDS RQNMI RKAQE DGSQG F |
| Synonyms: | ADCAD2, STHAG7 |
| Calculated MW: | 180kDa |
| Observed MW: | 180kDa |
Related Products
