LRBA Antibody (PACO28013)
- SKU:
- PACO28013
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | LRBA Antibody (PACO28013) |
| Antibody SKU: | PACO28013 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Lipopolysaccharide-responsive and beige-like anchor protein (2-252AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human placenta tissue using PACO28013 at dilution of 1:20. |
 | Immunofluorescent analysis of MCF-7 cells using PACO28013 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunofluorescent analysis of U251 cells using PACO28013 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | May be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules |
| Synonyms: | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein), LRBA, BGL CDC4L LBA |
| UniProt Protein Function: | May be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules. |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012] |
| UniProt Code: | P50851 |
| NCBI GenInfo Identifier: | 345498499 |
| NCBI Gene ID: | 987 |
| NCBI Accession: | NP_001186211.2 |
| UniProt Secondary Accession: | P50851,Q4W5J4, Q4W5L6, Q8NFQ0, Q9H2U3, Q9H2U4 |
| UniProt Related Accession: | P50851 |
| Molecular Weight: | 317,702 Da |
| NCBI Full Name: | lipopolysaccharide-responsive and beige-like anchor protein isoform 1 |
| NCBI Synonym Full Names: | LPS responsive beige-like anchor protein |
| NCBI Official Symbol: | LRBA |
| NCBI Official Synonym Symbols: | BGL; LBA; CDC4L; CVID8; LAB300 |
| NCBI Protein Information: | lipopolysaccharide-responsive and beige-like anchor protein |
| UniProt Protein Name: | Lipopolysaccharide-responsive and beige-like anchor protein |
| UniProt Synonym Protein Names: | Beige-like protein; CDC4-like protein |
| Protein Family: | Lipopolysaccharide-responsive and beige-like anchor protein |
| UniProt Gene Name: | LRBA |
| UniProt Entry Name: |
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