Name: LPA Antibody (PACO34866)
SKU: PACO34866
Availability: OutOfStock

Antibody Name:	LPA Antibody (PACO34866)
Antibody SKU:	PACO34866
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA
Recommended Dilutions:
Species Reactivity:	Human
Immunogen:	Recombinant Human Apolipoprotein(a) protein (3999-4112AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Background:	Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.
Synonyms:	Apolipoprotein(a) (Apo(a)) (Lp(a)) (EC 3.4.21.-), LPA

UniProt Protein Function:	LPA: Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330. Belongs to the peptidase S1 family. Plasminogen subfamily.
UniProt Protein Details:	Protein type:Inhibitor; Protease; EC 3.4.21.- Chromosomal Location of Human Ortholog: 6q26 Cellular Component: extracellular region Molecular Function:heparin binding; protein binding; serine-type endopeptidase activity; fibronectin binding; endopeptidase inhibitor activity; apolipoprotein binding Biological Process: receptor-mediated endocytosis; blood circulation; lipoprotein metabolic process; lipid metabolic process; lipid transport; proteolysis
NCBI Summary:	The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009]
UniProt Code:	P08519
NCBI GenInfo Identifier:	114062
NCBI Gene ID:	4018
NCBI Accession:	P08519.1
UniProt Secondary Accession:	P08519,Q5VTD7, Q9UD88,
UniProt Related Accession:	P08519
Molecular Weight:	280,000-700,000
NCBI Full Name:	Apolipoprotein(a)
NCBI Synonym Full Names:	lipoprotein, Lp(a)
NCBI Official Symbol:	LPA
NCBI Official Synonym Symbols:	LP; AK38; APOA
NCBI Protein Information:	apolipoprotein(a)
UniProt Protein Name:	Apolipoprotein(a)
Protein Family:	Late promoter-activating protein
UniProt Gene Name:	LPA
UniProt Entry Name:	APOA_HUMAN