Name: LOXL3 Antibody (PACO19954)
SKU: PACO19954
Availability: OutOfStock

Antibody Name:	LOXL3 Antibody (PACO19954)
Antibody SKU:	PACO19954
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide of human LOXL3

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19954(LOXL3 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid, sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined.

Synonyms:

lysyl oxidase-like 3

UniProt Protein Function:	LOXL3: a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
UniProt Protein Details:	Protein type:Secreted; EC 1.4.3.-; Secreted, signal peptide; Oxidoreductase Chromosomal Location of Human Ortholog: 2p13 Cellular Component: extracellular region; nucleus Molecular Function:protein binding Biological Process: epithelial to mesenchymal transition; negative regulation of transcription, DNA-dependent
NCBI Summary:	This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:	P58215
NCBI GenInfo Identifier:	14916616
NCBI Gene ID:	84695
NCBI Accession:	P58215.1
UniProt Secondary Accession:	P58215,Q2EHP2, Q6IPL7, Q96RS1, D6W5J1,
UniProt Related Accession:	P58215
Molecular Weight:	67,445 Da
NCBI Full Name:	Lysyl oxidase homolog 3
NCBI Synonym Full Names:	lysyl oxidase like 3
NCBI Official Symbol:	LOXL3
NCBI Official Synonym Symbols:	LOXL
NCBI Protein Information:	lysyl oxidase homolog 3
UniProt Protein Name:	Lysyl oxidase homolog 3
UniProt Synonym Protein Names:	Lysyl oxidase-like protein 3
Protein Family:	Lysyl oxidase
UniProt Gene Name:	LOXL3
UniProt Entry Name:	LOXL3_HUMAN