Lox Antibody (PACO27985)
- SKU:
- PACO27985
- Product Type:
- Antibody
- Reactivity:
- Rat
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Lox Antibody (PACO27985) |
| Antibody SKU: | PACO27985 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Rat, Human |
| Immunogen: | Recombinant Rat Protein-lysine 6-oxidas protein (163-411AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: Lox antibody at 2µg/ml + K562 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 47 kDa Observed band size: 47 kDa . |
| Background: | Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. |
| Synonyms: | Protein-lysine 6-oxidase (EC 1.4.3.13) (Lysyl oxidase), Lox |
| UniProt Protein Function: | LOX: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression. Belongs to the lysyl oxidase family.Protein type: EC 1.4.3.13; Oxidoreductase; Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 18q11Cellular Component: collagen; extracellular region; extracellular space; nucleus; proteinaceous extracellular matrixMolecular Function: copper ion binding; protein-lysine 6-oxidase activityBiological Process: blood vessel development; blood vessel morphogenesis; collagen fibril organization; elastic fiber assembly; heart development; lung development; response to drug; response to hormone stimulus; response to steroid hormone stimulus; wound healing |
| UniProt Protein Details: | |
| NCBI Summary: | enzyme involved in the catalysis of the reaction required for cross-linking of collagen and elastin fibers [RGD, Feb 2006] |
| UniProt Code: | P16636 |
| NCBI GenInfo Identifier: | 8393733 |
| NCBI Gene ID: | 24914 |
| NCBI Accession: | NP_058757.1 |
| UniProt Secondary Accession: | P16636 |
| UniProt Related Accession: | P16636 |
| Molecular Weight: | 46,559 Da |
| NCBI Full Name: | protein-lysine 6-oxidase |
| NCBI Synonym Full Names: | lysyl oxidase |
| NCBI Official Symbol: | Lox |
| NCBI Official Synonym Symbols: | Rrg1; H-rev142 |
| NCBI Protein Information: | protein-lysine 6-oxidase |
| UniProt Protein Name: | Protein-lysine 6-oxidase |
| UniProt Synonym Protein Names: | Lysyl oxidase |
| Protein Family: | Linoleate 9/13-lipoxygenase |
| UniProt Gene Name: | Lox |
| UniProt Entry Name: |
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