Description
Antibody Name: | LMCD1 Antibody (PACO58520) |
Antibody SKU: | PACO58520 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human LIM and cysteine-rich domains protein 1 protein (105-268AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
IHC image of PACO58520 diluted at 1:300 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. | |
Immunofluorescence staining of A549 cells with PACO58520 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
IHC image of PACO58520 diluted at 1:300 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
Background: | Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway. |
Synonyms: | LIM and cysteine-rich domains protein 1 (Dyxin), LMCD1 |
UniProt Protein Function: | LMCD1: Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue- specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter. Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.Protein type: Unknown functionChromosomal Location of Human Ortholog: 3p26-p24Cellular Component: extracellular matrix; extracellular space; cytoplasm; nucleusMolecular Function: zinc ion binding; transcription corepressor activityBiological Process: transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a member of the LIM-domain family of zinc finger proteins. The encoded protein contains an N-terminal cysteine-rich domain and two C-terminal LIM domains. The presence of LIM domains suggests involvement in protein-protein interactions. The protein may act as a co-regulator of transcription along with other transcription factors. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013] |
UniProt Code: | Q9NZU5 |
NCBI GenInfo Identifier: | 20978521 |
NCBI Gene ID: | 29995 |
NCBI Accession: | Q9NZU5.1 |
UniProt Secondary Accession: | Q9NZU5,B4DG80 |
UniProt Related Accession: | Q9NZU5 |
Molecular Weight: | 32,882 Da |
NCBI Full Name: | LIM and cysteine-rich domains protein 1 |
NCBI Synonym Full Names: | LIM and cysteine-rich domains 1 |
NCBI Official Symbol: | LMCD1 |
NCBI Official Synonym Symbols: | |
NCBI Protein Information: | LIM and cysteine-rich domains protein 1; dyxin |
UniProt Protein Name: | LIM and cysteine-rich domains protein 1 |
UniProt Synonym Protein Names: | Dyxin |
Protein Family: | LIM and cysteine-rich domains protein |
UniProt Gene Name: | LMCD1 |
UniProt Entry Name: | LMCD1_HUMAN |