LIM kinase 1(LIMK1) Monoclonal Antibody
- SKU:
- CAB23948
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | LIM kinase 1(LIMK1) Monoclonal Antibody |
| Product Code: | CAB23948 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC61299 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:1000-1:5000, IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | 293F |
| Cellular Location: | Cytoplasm, Nucleus |
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 630-647 of human LIM kinase 1(LIMK1)(NP_002305.1). |
| Sequence: | NADPD YLPRT MDFGL NVRGF LDRYC PPNCP PSFFP ITVRC CDLDP EKRPS FVKLE HWLET LRMHL AGHLP LGPQL EQLDR GFWET YRRGE SGLPA HPEVP D |
| Synonyms: | LIMK1, LIMK, LIMK-1, LIM domain kinase 1 |
| Calculated MW: | 33kDa/68kDa/70kDa/72kDa |
| Observed MW: | 74kDa |
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