LILRA3 Antibody (PACO58324)
- SKU:
- PACO58324
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | LILRA3 Antibody (PACO58324) |
| Antibody SKU: | PACO58324 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Leukocyte immunoglobulin-like receptor subfamily A member 3 protein (222-313AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: A549 whole cell lysate, Jurkat whole cell lysate. All lanes: LILRA3 antibody at 4.2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 48, 41, 50 kDa. Observed band size: 48 kDa. |
 | IHC image of PACO58324 diluted at 1:300 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-α production by monocytes. |
| Synonyms: | Leukocyte immunoglobulin-like receptor subfamily A member 3 (CD85 antigen-like family member E) (Immunoglobulin-like transcript 6) (ILT-6) (Leukocyte immunoglobulin-like receptor 4) (LIR-4) (Monocyte inhibitory receptor HM43/HM31) (CD antigen CD85e), LILRA3, ILT6 LIR4 |
| UniProt Protein Function: | LILRA3: May act as soluble receptor for class I MHC antigens.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 19q13.4Cellular Component: plasma membraneMolecular Function: antigen binding; receptor activityBiological Process: defense response; signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of a family of immunoreceptors that are expressed predominantly in monocytes and B cells, and at lower levels in dendritic cells and natural killer cells. The encoded protein lacks the transmembrane region found in other members of this family. It acts as a soluble receptor for class I major histocompatibility complex (MHC) antigens. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and is polymorphic in human populations, with many individuals containing a deletion of this genomic region. [provided by RefSeq, Mar 2014] |
| UniProt Code: | Q8N6C8 |
| NCBI GenInfo Identifier: | 92090611 |
| NCBI Gene ID: | 11026 |
| NCBI Accession: | Q8N6C8.3 |
| UniProt Secondary Accession: | Q8N6C8,O15469, O15470, O75016, Q8N151, Q8N154, Q8NHJ1 Q8NHJ2, Q8NHJ3, Q8NHJ4 |
| UniProt Related Accession: | Q8N6C8 |
| Molecular Weight: | 49,187 Da |
| NCBI Full Name: | Leukocyte immunoglobulin-like receptor subfamily A member 3 |
| NCBI Synonym Full Names: | leukocyte immunoglobulin like receptor A3 |
| NCBI Official Symbol: | LILRA3 |
| NCBI Official Synonym Symbols: | HM31; HM43; ILT6; LIR4; CD85E; ILT-6; LIR-4 |
| NCBI Protein Information: | leukocyte immunoglobulin-like receptor subfamily A member 3 |
| UniProt Protein Name: | Leukocyte immunoglobulin-like receptor subfamily A member 3 |
| UniProt Synonym Protein Names: | CD85 antigen-like family member E; Immunoglobulin-like transcript 6; ILT-6; Leukocyte immunoglobulin-like receptor 4; LIR-4; Monocyte inhibitory receptor HM43/HM31; CD_antigen: CD85e |
| Protein Family: | Leukocyte immunoglobulin-like receptor subfamily |
| UniProt Gene Name: | LILRA3 |
| UniProt Entry Name: | LIRA3_HUMAN |
Related Products
Human ILT6/LILRA3 Recombinant Protein (His tag)
OverviewProduct Name:Human ILT6/LILRA3 Recombinant Protein (His tag)Product Code:RPES6062Size:20µgSpecies:Human
Human ILT6/LILRA3 Recombinant Protein (RPES3422)
system_update_altDatasheetHuman ILT6/LILRA3 Recombinant Protein Leukocyte immunoglobulin-like receptor subfamily A member 3 is also known as CD85 antigen-like family member E, Immunoglobulin-like
Human ILT6/LILRA3 Recombinant Protein (RPES3820)
system_update_altDatasheetHuman ILT6/LILRA3 Recombinant Protein ILT6, also known as LILRA3, belongs to the ILT family. In human, the ILT gene family includes up to 11 members. The extracellular p
Human LILRA3 (ILT-6/CD85e) PharmaGenie ELISA Kit (SBRS0833)
system_update_altDatasheetHuman LILRA3 (ILT-6/CD85e) PharmaGenie ELISA Kit (SBRS0833)Overview
