lepA Antibody (PACO34594)
- SKU:
- PACO34594
- Product Type:
- Antibody
- Reactivity:
- Bacteria - Escherichia coli
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | lepA Antibody (PACO34594) |
| Antibody SKU: | PACO34594 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Escherichia coli |
| Immunogen: | Recombinant Escherichia coli Elongation factor 4 protein (1-599AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. |
| Synonyms: | Elongation factor 4 (EF-4) (EC 3.6.5.n1) (Ribosomal back-translocase LepA), lepA |
| UniProt Protein Function: | Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. |
| UniProt Protein Details: | |
| NCBI Summary: | Although EF4 improves translational accuracy, it can not reverse paromomycin-induced errors (Qin, 2006). [More information is available at EcoGene: EG10529]. LepA is an elongation factor that induces back-translocation of the ribosome. [More information is available at EcoCyc: EG10529]. |
| UniProt Code: | P60785 |
| NCBI GenInfo Identifier: | 16130494 |
| NCBI Gene ID: | 947051 |
| NCBI Accession: | NP_417064.1 |
| UniProt Secondary Accession: | P60785,P07682, P76590, Q2MAG1 |
| UniProt Related Accession: | P60785 |
| Molecular Weight: | 66,570 Da |
| NCBI Full Name: | back-translocating elongation factor EF4, GTPase |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | lepA |
| NCBI Official Synonym Symbols: | ECK2567; JW2553 |
| NCBI Protein Information: | back-translocating elongation factor EF4, GTPase |
| UniProt Protein Name: | Elongation factor 4 |
| UniProt Synonym Protein Names: | Ribosomal back-translocase LepA |
| Protein Family: | Leptin |
| UniProt Gene Name: | lepA |
| UniProt Entry Name: | LEPA_ECOLI |
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