Name: LDOC1 Antibody (PACO16610)
SKU: PACO16610
Availability: OutOfStock

Antibody Name:	LDOC1 Antibody (PACO16610)
Antibody SKU:	PACO16610
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:	Human
Immunogen:	Fusion protein of human LDOC1

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO16610(LDOC1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).

Background:

The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor κ B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers.

Synonyms:

leucine zipper, down-regulated in cancer 1

UniProt Protein Function:	LDOC1: May have an important role in the development and/or progression of some cancers. Belongs to the LDOC1 family.Protein type: Cell cycle regulationChromosomal Location of Human Ortholog: Xq27Cellular Component: nucleolus; nucleusMolecular Function: protein bindingBiological Process: negative regulation of cell proliferation
UniProt Protein Details:
NCBI Summary:	The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. [provided by RefSeq, Jul 2008]
UniProt Code:	O95751
NCBI GenInfo Identifier:	6912480
NCBI Gene ID:	23641
NCBI Accession:	NP_036449
UniProt Secondary Accession:	O95751
UniProt Related Accession:	O95751
Molecular Weight:	17kDa
NCBI Full Name:	protein LDOC1
NCBI Synonym Full Names:	LDOC1 regulator of NFKB signaling
NCBI Official Symbol:	LDOC1
NCBI Official Synonym Symbols:	Mar7; RTL7; BCUR1; Mart7; SIRH7
NCBI Protein Information:	protein LDOC1
UniProt Protein Name:	Protein LDOC1
UniProt Synonym Protein Names:	Leucine zipper protein down-regulated in cancer cells
Protein Family:	Protein
UniProt Gene Name:	LDOC1
UniProt Entry Name:	LDOC1_HUMAN