LCOR Antibody (PACO61666)
- SKU:
- PACO61666
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | LCOR Antibody (PACO61666) |
| Antibody SKU: | PACO61666 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Ligand-dependent corepressor protein (13-144AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, A549 whole cell lysate. All lanes: LCOR antibody at 4.6µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 48, 45, 107 kDa. Observed band size: 48 kDa. |
| Background: | May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR. |
| Synonyms: | Ligand-dependent corepressor, LCoR, Mblk1-related protein 2, LCOR |
| UniProt Protein Function: | LCOR: May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand- dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Nuclear receptor co-regulatorChromosomal Location of Human Ortholog: 10q24Cellular Component: nucleusMolecular Function: DNA binding; transcription factor activity; transcription factor bindingBiological Process: transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter |
| UniProt Protein Details: | |
| NCBI Summary: | LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q96JN0 |
| NCBI GenInfo Identifier: | 282847508 |
| NCBI Gene ID: | 84458 |
| NCBI Accession: | NP_115816.2 |
| UniProt Secondary Accession: | Q96JN0,Q5VW16, Q7Z723, Q86T32, Q86T33, Q8N3L6, D3DR47 |
| UniProt Related Accession: | Q96JN0 |
| Molecular Weight: | 44,083 Da |
| NCBI Full Name: | ligand-dependent corepressor isoform 1 |
| NCBI Synonym Full Names: | ligand dependent nuclear receptor corepressor |
| NCBI Official Symbol: | LCOR |
| NCBI Official Synonym Symbols: | MLR2 |
| NCBI Protein Information: | ligand-dependent corepressor; mblk1-related protein 2 |
| UniProt Protein Name: | Ligand-dependent corepressor |
| UniProt Synonym Protein Names: | Mblk1-related protein 2 |
| Protein Family: | Ligand-dependent corepressor |
| UniProt Gene Name: | LCOR |
| UniProt Entry Name: | LCOR_HUMAN |
| Antibodies |
| LCOR Antibody (PACO10211) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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