Name: LCMT1 Antibody (PACO16608)
SKU: PACO16608
Availability: OutOfStock

Antibody Name:	LCMT1 Antibody (PACO16608)
Antibody SKU:	PACO16608
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:	Human, Rat
Immunogen:	Fusion protein of human LCMT1

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO16608(LCMT1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16608(LCMT1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).

Background:	LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A.
Synonyms:	leucine carboxyl methyltransferase 1

UniProt Protein Function:	LCMT1: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. Belongs to the methyltransferase superfamily. LCMT family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - histidine; EC 2.1.1.233; Lipid Metabolism - androgen and estrogen; Methyltransferase; Other Amino Acids Metabolism - selenoamino acidChromosomal Location of Human Ortholog: 16p12.1Cellular Component: cytosolMolecular Function: protein binding; C-terminal protein carboxyl methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activityBiological Process: regulation of apoptosis; protein amino acid methylation; C-terminal protein amino acid methylation; protein modification process; negative regulation of protein complex assembly
UniProt Protein Details:
NCBI Summary:	LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA; MIM 176915) (De Baere et al., 1999 [PubMed 10600115]).[supplied by OMIM, Mar 2008]
UniProt Code:	Q9UIC8
NCBI GenInfo Identifier:	74048545
NCBI Gene ID:	51451
NCBI Accession:	NP_001027563.1
UniProt Secondary Accession:	Q9UIC8,Q53FC5, Q96CI5, Q9H6I9, Q9NTG4, Q9Y378, A6NL89 A8K770
UniProt Related Accession:	Q9UIC8
Molecular Weight:	32,172 Da
NCBI Full Name:	leucine carboxyl methyltransferase 1 isoform b
NCBI Synonym Full Names:	leucine carboxyl methyltransferase 1
NCBI Official Symbol:	LCMT1
NCBI Official Synonym Symbols:	LCMT; PPMT1; CGI-68
NCBI Protein Information:	leucine carboxyl methyltransferase 1; [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1; protein phosphatase methyltransferase 1; protein-leucine O-methyltransferase
UniProt Protein Name:	Leucine carboxyl methyltransferase 1
UniProt Synonym Protein Names:	Protein-leucine O-methyltransferase; [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1
Protein Family:	Leucine carboxyl methyltransferase
UniProt Gene Name:	LCMT1
UniProt Entry Name:	LCMT1_HUMAN