LAT2 Antibody (PACO14639)
- SKU:
- PACO14639
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | LAT2 Antibody (PACO14639) |
| Antibody SKU: | PACO14639 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:10-1:50 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human LAT2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14639(LAT2 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin γ Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. |
| Synonyms: | linker for activation of T cells family, member 2 |
| UniProt Protein Function: | LAB: linker for activation of B cells (LAB) is an adaptor protein. B cell antigen receptor signaling leads to its phosphorylation and interaction with the adaptor protein Grb2. Decreased expression leads to a reduction in BCR-mediated calcium flux and Erk activation. Localized to lipid rafts. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Membrane protein, integral Chromosomal Location of Human Ortholog: 7q11.23 Cellular Component: mast cell granule; integral to membrane; plasma membrane; lipid raft Molecular Function:protein binding; SH2 domain binding Biological Process: B cell receptor signaling pathway; B cell activation; calcium-mediated signaling; innate immune response; mast cell degranulation |
| NCBI Summary: | This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9GZY6 |
| NCBI GenInfo Identifier: | 74752543 |
| NCBI Gene ID: | 7462 |
| NCBI Accession: | Q9GZY6.1 |
| UniProt Secondary Accession: | Q9GZY6,Q9BXX8, Q9NZY9, A6NFK6, A8K209, A8K4F1, D3DXF9 |
| UniProt Related Accession: | Q9GZY6 |
| Molecular Weight: | 12,255 Da |
| NCBI Full Name: | Linker for activation of T-cells family member 2 |
| NCBI Synonym Full Names: | linker for activation of T cells family, member 2 |
| NCBI Official Symbol: | LAT2 |
| NCBI Official Synonym Symbols: | LAB; NTAL; WSCR5; WBSCR5; HSPC046; WBSCR15 |
| NCBI Protein Information: | linker for activation of T-cells family member 2; non-T-cell activation linker; linker for activation of B-cells; membrane-associated adapter molecule; Williams-Beuren syndrome chromosomal region 5 protein; Williams-Beuren syndrome chromosomal region 15 protein; linker for activation of T cells, transmembrane adaptor 2 |
| UniProt Protein Name: | Linker for activation of T-cells family member 2 |
| UniProt Synonym Protein Names: | Linker for activation of B-cells; Membrane-associated adapter molecule; Non-T-cell activation linker; Williams-Beuren syndrome chromosomal region 15 protein; Williams-Beuren syndrome chromosomal region 5 protein |
| Protein Family: | Linker for activation of T-cells family |
| UniProt Gene Name: | LAT2 |
| UniProt Entry Name: | NTAL_HUMAN |
| Antibodies |
| LAT2 Antibody (PACO10202) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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