Description
Antibody Name: | LAT2 Antibody (PACO10202) |
Antibody SKU: | PACO10202 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | |
Species Reactivity: | Human |
Immunogen: | Human LAT2 |
Form: | Liquid |
Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | linker for activation of T cells family, member 2;LAT2;HSPC046;LAB;NTAL;WBSCR15;WBSCR5;WSCR5 ; |
UniProt Protein Function: | LAB: linker for activation of B cells (LAB) is an adaptor protein. B cell antigen receptor signaling leads to its phosphorylation and interaction with the adaptor protein Grb2. Decreased expression leads to a reduction in BCR-mediated calcium flux and Erk activation. Localized to lipid rafts. |
UniProt Protein Details: | Protein type:Adaptor/scaffold; Membrane protein, integral Chromosomal Location of Human Ortholog: 7q11.23 Cellular Component: mast cell granule; integral to membrane; plasma membrane; lipid raft Molecular Function:protein binding; SH2 domain binding Biological Process: B cell receptor signaling pathway; B cell activation; calcium-mediated signaling; innate immune response; mast cell degranulation |
NCBI Summary: | This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9GZY6 |
NCBI GenInfo Identifier: | 74752543 |
NCBI Gene ID: | 7462 |
NCBI Accession: | Q9GZY6.1 |
UniProt Secondary Accession: | Q9GZY6,Q9BXX8, Q9NZY9, A6NFK6, A8K209, A8K4F1, D3DXF9 |
UniProt Related Accession: | Q9GZY6 |
Molecular Weight: | 12,255 Da |
NCBI Full Name: | Linker for activation of T-cells family member 2 |
NCBI Synonym Full Names: | linker for activation of T cells family, member 2 |
NCBI Official Symbol: | LAT2 |
NCBI Official Synonym Symbols: | LAB; NTAL; WSCR5; WBSCR5; HSPC046; WBSCR15 |
NCBI Protein Information: | linker for activation of T-cells family member 2; non-T-cell activation linker; linker for activation of B-cells; membrane-associated adapter molecule; Williams-Beuren syndrome chromosomal region 5 protein; Williams-Beuren syndrome chromosomal region 15 protein; linker for activation of T cells, transmembrane adaptor 2 |
UniProt Protein Name: | Linker for activation of T-cells family member 2 |
UniProt Synonym Protein Names: | Linker for activation of B-cells; Membrane-associated adapter molecule; Non-T-cell activation linker; Williams-Beuren syndrome chromosomal region 15 protein; Williams-Beuren syndrome chromosomal region 5 protein |
Protein Family: | Linker for activation of T-cells family |
UniProt Gene Name: | LAT2 |
UniProt Entry Name: | NTAL_HUMAN |