lasA Antibody (PACO34142)
- SKU:
- PACO34142
- Product Type:
- Antibody
- Reactivity:
- Bacteria
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | lasA Antibody (PACO34142) |
| Antibody SKU: | PACO34142 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Pseudomonas aeruginosa |
| Immunogen: | Recombinant Pseudomonas aeruginosa Protease LasA protein (237-418AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Involved in proteolysis and elastolysis (degradation of the host protein elastin). Has staphylolytic activity (degrades pentaglycine cross-links in cell wall peptidogylcan), preferring Gly-Gly- |-X substrates where X is Ala or Gly. Enhances the elastolytic but not proteolytic activity of elastase (lasB) and elastolytic activity of other proteases. Degradation of host elastin is likely to contribute to the pathogenicity of P.aeruginosa. While either His-317 or His-356 can abstract a proton in the hydrolysis reaction, the same residue performs both functions in a given catalytic cycle, with the other stabilizing the catalytic intermediate. |
| Synonyms: | Protease LasA (EC 3.4.24.-) (Staphylolytic protease), lasA |
| UniProt Protein Function: | Involved in proteolysis and elastolysis (degradation of the host protein elastin). Has staphylolytic activity (degrades pentaglycine cross-links in cell wall peptidogylcan), preferring Gly-Gly-|-X substrates where X is Ala or Gly (PubMed:11179971). Enhances the elastolytic but not proteolytic activity of elastase (lasB) and elastolytic activity of other proteases (PubMed:2110137). Degradation of host elastin is likely to contribute to the pathogenicity of P.aeruginosa. While either His-317 or His-356 can abstract a proton in the hydrolysis reaction, the same residue performs both functions in a given catalytic cycle, with the other stabilizing the catalytic intermediate (PubMed:20026068). |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P14789 |
| NCBI GenInfo Identifier: | 15597068 |
| NCBI Gene ID: | 878260 |
| NCBI Accession: | NP_250562.1 |
| UniProt Secondary Accession: | P14789,P72165, Q9I2M5 |
| UniProt Related Accession: | P14789 |
| Molecular Weight: | 36 kDa |
| NCBI Full Name: | LasA protease |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | lasA |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | LasA protease |
| UniProt Protein Name: | Protease LasA |
| UniProt Synonym Protein Names: | Staphylolytic protease |
| Protein Family: | Protease |
| UniProt Gene Name: | lasA |
| UniProt Entry Name: | LASA_PSEAE |
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