LAS1L Antibody (PACO57616)
- SKU:
- PACO57616
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | LAS1L Antibody (PACO57616) |
| Antibody SKU: | PACO57616 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IF:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Ribosomal biogenesis protein LAS1L protein (490-565AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: 293 whole cell lysate. All lanes: LAS1L antibody at 3.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 84, 82, 77, 34 kDa. Observed band size: 84 kDa. |
 | Immunofluorescence staining of HepG2 cells with PACO57616 at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. |
| Synonyms: | Ribosomal biogenesis protein LAS1L (Protein LAS1 homolog), LAS1L |
| UniProt Protein Function: | LAS1L: a protein of unknown function. Protein type: Nucleolus; RNA-bindingChromosomal Location of Human Ortholog: Xq12Cellular Component: cytoplasm; membrane; microtubule organizing center; nucleoplasmBiological Process: endonucleolytic cleavages during rRNA processing; establishment and/or maintenance of chromatin architecture; maturation of 5.8S rRNA; maturation of LSU-rRNA; rRNA processing |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9Y4W2 |
| NCBI GenInfo Identifier: | 73920837 |
| NCBI Gene ID: | 81887 |
| NCBI Accession: | Q9Y4W2.2 |
| UniProt Secondary Accession: | Q9Y4W2,Q5JXQ0, Q8TEN5, Q9H9V5, A9X410 |
| UniProt Related Accession: | Q9Y4W2 |
| Molecular Weight: | 33,108 Da |
| NCBI Full Name: | Ribosomal biogenesis protein LAS1L |
| NCBI Synonym Full Names: | LAS1 like, ribosome biogenesis factor |
| NCBI Official Symbol: | LAS1L |
| NCBI Official Synonym Symbols: | Las1-like; dJ475B7.2 |
| NCBI Protein Information: | ribosomal biogenesis protein LAS1L |
| UniProt Protein Name: | Ribosomal biogenesis protein LAS1L |
| UniProt Synonym Protein Names: | Protein LAS1 homolog |
| Protein Family: | Ribosomal biogenesis protein |
| UniProt Gene Name: | LAS1L |
| UniProt Entry Name: | LAS1L_HUMAN |
| Antibodies |
| LAS1L Antibody (PACO10199) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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