LAMA5 Antibody (PACO18135)
- SKU:
- PACO18135
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | LAMA5 Antibody (PACO18135) |
| Antibody SKU: | PACO18135 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:10-1:50 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human LAMA5 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO18135(LAMA5 Antibody) at dilution 1/8, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and γ chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the α subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined. |
| Synonyms: | laminin, α 5 |
| UniProt Protein Function: | LAMA5: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Extracellular matrix; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 20q13.2-q13.3 Cellular Component: extracellular matrix; extracellular space; laminin-5 complex; laminin-1 complex; laminin-10 complex; extracellular region; basement membrane; basal lamina; nucleus Molecular Function:integrin binding; structural molecule activity Biological Process: integrin-mediated signaling pathway; regulation of cell adhesion; focal adhesion formation; endothelial cell differentiation; extracellular matrix organization and biogenesis; muscle development; cell migration; regulation of embryonic development; cell recognition; cytoskeleton organization and biogenesis; regulation of cell migration; regulation of cell proliferation; odontogenesis of dentine-containing teeth; cell proliferation; extracellular matrix disassembly; embryonic development; morphogenesis of embryonic epithelium; hair follicle development; ureteric bud branching; cilium biogenesis; angiogenesis; cell differentiation; neural crest cell migration; morphogenesis of a polarized epithelium; lung development |
| NCBI Summary: | This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). [provided by RefSeq, Jun 2013] |
| UniProt Code: | O15230 |
| NCBI GenInfo Identifier: | 21264602 |
| NCBI Gene ID: | 3911 |
| NCBI Accession: | |
| UniProt Related Accession: | O15230 |
| Molecular Weight: | |
| NCBI Full Name: | laminin subunit alpha-5 |
| NCBI Synonym Full Names: | laminin subunit alpha 5 |
| NCBI Official Symbol: | LAMA5 |
| NCBI Protein Information: | laminin subunit alpha-5 |
| UniProt Protein Name: | Laminin subunit alpha-5 |
| UniProt Synonym Protein Names: | Laminin-10 subunit alpha; Laminin-11 subunit alpha; Laminin-15 subunit alpha |
| UniProt Gene Name: | LAMA5 |
| UniProt Entry Name: | LAMA5_HUMAN |
| Antibodies | ELISA Kits |
| LAMA5 Antibody (PACO02865) | Human Laminin subunit alpha-5 / LAMA5 ELISA Kit |
| Human Laminin subunit alpha-5 (LAMA5) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
Human anti-LAMA5(Laminin subunit alpha-5)antibody Elisa kit
