L2 Antibody (PACO34694)

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SKU:
PACO34694
Product Type:
Antibody
Reactivity:
Virus
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:L2 Antibody (PACO34694)
Antibody SKU:PACO34694
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Human papillomavirus type 18
Immunogen:Recombinant Human papillomavirus type 18 Minor capsid protein L2 protein (1-462AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid protein L1. Once the virion enters the host cell, escorts the genomic DNA into the nucleus, in particular by promoting virion endosomal escape. It is involved, through its interaction with host dynein, in the intracellular microtubule-dependent transport of viral capsid toward the nucleus. Mediates the viral genome import into the nucleus through binding to host importins. Mediates the viral genome import into the nucleus through binding to host importins. Once within the nucleus, L2 localizes viral genomes to PML bodies in order to activate early gene expression for establishment of infection. Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions. During virion assembly, encapsidates the genome by direct interaction with the viral DNA (By similarity).
Synonyms:Minor capsid protein L2, L2
UniProt Protein Function:Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid protein L1. Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network. Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus. Mediates the viral genome import into the nucleus through binding to host importins. Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection. Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions. During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
UniProt Protein Details:
NCBI Summary:
UniProt Code:P06793
NCBI GenInfo Identifier:
NCBI Gene ID:1489091
NCBI Accession:NP_040316.1
UniProt Secondary Accession:P06793
UniProt Related Accession:P06793,CAA28670
Molecular Weight:51.6 kDa
NCBI Full Name:
NCBI Synonym Full Names:
NCBI Official Symbol:L2  
NCBI Official Synonym Symbols:
NCBI Protein Information:L2 protein
UniProt Protein Name:Minor capsid protein L2
UniProt Synonym Protein Names:
Protein Family:Penton protein
UniProt Gene Name:L2  
UniProt Entry Name:VL2_HPV18
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