Description
Antibody Name: | L1 Antibody (PACO32592) |
Antibody SKU: | PACO32592 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
Species Reactivity: | Human papillomavirus type 18 |
Immunogen: | Recombinant HPV18 Major capsid protein L1 protein (1-568AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot All lanes: Major capsid protein L1 antibody at 2µg/ml + 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 62 kDa Observed band size: 62 kDa . |
Background: | Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on the basement membrane to provide initial virion attachment to target cells. Basement membrane is exposed only after epithelium trauma. Additionally, the alpha6 integrin complexed with either beta1 or beta4 integrin has been proposed to act as a coreceptor recognized by L1. Once attached, integrin complexed with beta4 integrin has been proposed to act as a coreceptor recognized by L1. Once attached, the virion enters the host cell via clathrin-mediated endocytosis and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2. |
Synonyms: | Major capsid protein L1, L1 |
UniProt Protein Function: | Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2. |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | P06794 |
NCBI GenInfo Identifier: | 9626077 |
NCBI Gene ID: | 1489090 |
NCBI Accession: | NP_040317.1 |
UniProt Secondary Accession: | P06794,Q84270 |
UniProt Related Accession: | P06794 |
Molecular Weight: | |
NCBI Full Name: | L1 protein |
NCBI Synonym Full Names: | |
NCBI Official Symbol: | |
NCBI Official Synonym Symbols: | |
NCBI Protein Information: | |
UniProt Protein Name: | Major capsid protein L1 |
UniProt Synonym Protein Names: | |
Protein Family: | Packaging protein |
UniProt Gene Name: | L1 |
UniProt Entry Name: | VL1_HPV18 |