Antibody Name:	KRT17 Antibody (PACO27853)
Antibody SKU:	PACO27853
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA
Recommended Dilutions:
Species Reactivity:	Bovine
Immunogen:	Recombinant Bovine Keratin, type I cytoskeletal 17 protein (1-441AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Background:

Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-α in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.

Synonyms:

Keratin, type I cytoskeletal 17 (Cytokeratin-17) (CK-17) (Keratin-17) (K17), KRT17

UniProt Protein Function:	Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
UniProt Protein Details:
NCBI Summary:
UniProt Code:	A1L595
NCBI GenInfo Identifier:	157427776
NCBI Gene ID:	281889
NCBI Accession:	NP_001098792.1
UniProt Secondary Accession:	A1L595,A5PJJ6
UniProt Related Accession:	A1L595
Molecular Weight:	64.7 kDa
NCBI Full Name:	keratin, type I cytoskeletal 17
NCBI Synonym Full Names:
NCBI Official Symbol:	KRT17
NCBI Official Synonym Symbols:
NCBI Protein Information:	keratin, type I cytoskeletal 17
UniProt Protein Name:	Keratin, type I cytoskeletal 17
UniProt Synonym Protein Names:	Cytokeratin-17; CK-17; Keratin-17; K17
Protein Family:	Keratin
UniProt Gene Name:	KRT17
UniProt Entry Name:	K1C17_BOVIN