KRT14/KRT16 Antibody (PACO06965)

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SKU:
PACO06965
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Applications:
WB
Applications:
IHC
Applications:
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated

Description

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Antibody Name:KRT14/KRT16 Antibody (PACO06965)
Antibody SKU:PACO06965
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:ELISA:1:20000, WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:Human, Mouse, Rat
Immunogen:Synthesized peptide derived from the N-terminal region of human Cytokeratin 14/16.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern Blot analysis of NIH-3T3 cells using Cytokeratin 14/16 Polyclonal Antibody.
Product ImageWestern Blot analysis of 3T3 cells using Cytokeratin 14/16 Polyclonal Antibody.
Synonyms:KRT14; Keratin; type I cytoskeletal 14; Cytokeratin-14; CK-14; Keratin-14; K14; KRT16; KRT16A; Keratin, type I cytoskeletal 16; Cytokeratin-16; CK-16; Keratin-16; K16
UniProt Protein Function:K14: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K5.
UniProt Protein Details:

Protein type:Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: cytoplasm; keratin filament; intermediate filament; cytosol; nucleus

Molecular Function:protein binding; structural constituent of cytoskeleton

Biological Process: epidermis development; hemidesmosome assembly; epithelial cell differentiation; response to zinc ion; response to ionizing radiation; intermediate filament bundle assembly; hair cycle; aging

Disease: Epidermolysis Bullosa Simplex, Localized; Epidermolysis Bullosa Simplex, Generalized; Dermatopathia Pigmentosa Reticularis; Epidermolysis Bullosa Simplex, Autosomal Recessive 1; Naegeli Syndrome; Epidermolysis Bullosa Simplex, Dowling-meara Type

NCBI Summary:This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq, Jul 2008]
UniProt Code:P02533
NCBI GenInfo Identifier:229463044
NCBI Gene ID:3861
NCBI Accession:P02533.4
UniProt Secondary Accession:P02533,P08779,
UniProt Related Accession:P02533
Molecular Weight:~ 52kDa
NCBI Full Name:Keratin, type I cytoskeletal 14
NCBI Synonym Full Names:keratin 14
NCBI Official Symbol:KRT14  
NCBI Official Synonym Symbols:K14; NFJ; CK14; EBS3; EBS4  
NCBI Protein Information:keratin, type I cytoskeletal 14
UniProt Protein Name:Keratin, type I cytoskeletal 14
UniProt Synonym Protein Names:Cytokeratin-14; CK-14; Keratin-14; K14
Protein Family:Putative outer capsid protein
UniProt Gene Name:KRT14  
UniProt Entry Name:K1C14_HUMAN
ELISA Kits
Keratin 14 Colorimetric Cell-Based ELISA
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