UniProt Protein Function: | Function: 1 Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting. |
UniProt Protein Details: | |
NCBI Summary: | precursor protein of kinin which is found in plasma; cysteine protease inhibitor and a major acute phase reactant [RGD, Feb 2006] |
UniProt Code: | P08934 |
NCBI GenInfo Identifier: | 7549773 |
NCBI Gene ID: | 25087 |
NCBI Accession: | NP_036873.1 |
UniProt Secondary Accession: | P08934 |
UniProt Related Accession: | P08934 |
Molecular Weight: | |
NCBI Full Name: | kininogen-1 isoform 1 |
NCBI Synonym Full Names: | kininogen 2-like 1 |
NCBI Official Symbol: | Kng2l1 |
NCBI Official Synonym Symbols: | Kng1; Kng2; Kngk; KINKG; KINKH; kininogen |
NCBI Protein Information: | kininogen-1 |
UniProt Protein Name: | Kininogen-1 |
UniProt Synonym Protein Names: | |
Protein Family: | |
UniProt Gene Name: | Kng1 |
UniProt Entry Name: | KNG1_RAT |