KLLN Antibody (PACO19913)
- SKU:
- PACO19913
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | KLLN Antibody (PACO19913) |
| Antibody SKU: | PACO19913 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human KLLN |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: MCF7 cells, Hela cells, Primary antibody: PACO19913(KLLN Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes. |
| Background: | The protein encoded by this intronless gene is found in the nucleus, where it can inhibit DNA synthesis and promote S phase arrest coupled to apoptosis. The expression of this DNA binding protein is upregulated by transcription factor p53. |
| Synonyms: | killin, p53-regulated DNA replication inhibitor |
| UniProt Protein Function: | KILLIN: DNA-binding protein involved in S phase checkpoint control-coupled apoptosis by mediating p53/TP53-induced apoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled to apoptosis. Has affinity to both double- and single- stranded DNA.Chromosomal Location of Human Ortholog: 10q23Cellular Component: nucleolus; nucleusBiological Process: apoptosis; cell cycle arrestDisease: Cowden Syndrome 4 |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this intronless gene is found in the nucleus, where it can inhibit DNA synthesis and promote S phase arrest coupled to apoptosis. The expression of this DNA binding protein is upregulated by transcription factor p53. [provided by RefSeq, Dec 2012] |
| UniProt Code: | B2CW77 |
| NCBI GenInfo Identifier: | 205809545 |
| NCBI Gene ID: | 100144748 |
| NCBI Accession: | B2CW77.1 |
| UniProt Secondary Accession: | B2CW77 |
| UniProt Related Accession: | B2CW77 |
| Molecular Weight: | 19,958 Da |
| NCBI Full Name: | Killin |
| NCBI Synonym Full Names: | killin, p53-regulated DNA replication inhibitor |
| NCBI Official Symbol: | KLLN |
| NCBI Official Synonym Symbols: | CWS4; KILLIN |
| NCBI Protein Information: | killin |
| UniProt Protein Name: | Killin |
| UniProt Synonym Protein Names: | |
| Protein Family: | Killin |
| UniProt Gene Name: | KLLN |
| UniProt Entry Name: | KILIN_HUMAN |
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