KLHL22 Antibody (PACO36114)
- SKU:
- PACO36114
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | KLHL22 Antibody (PACO36114) |
| Antibody SKU: | PACO36114 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Kelch-like protein 22 protein (2-300AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: KLHL22 antibody at 8µg/ml. Lane 1: Jurkat whole cell lysate. Lane 2: NIH/3T3 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 72, 56 kDa. Observed band size: 72 kDa. |
| Background: | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation. |
| Synonyms: | Kelch-like protein 22, KLHL22 |
| UniProt Protein Function: | KLHL22: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for cell division. BCR E3 ubiquitin ligase complexes mediate the ubiquitination of target proteins.Chromosomal Location of Human Ortholog: 22q11.21Cellular Component: centrosome; cytoplasm; polar microtubuleMolecular Function: protein binding; ubiquitin-protein ligase activityBiological Process: cell division; mitotic cell cycle spindle assembly checkpoint; mitotic sister chromatid segregation; protein monoubiquitination |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q53GT1 |
| NCBI GenInfo Identifier: | 109892504 |
| NCBI Gene ID: | 84861 |
| NCBI Accession: | Q53GT1.2 |
| UniProt Secondary Accession: | Q53GT1,Q96B68, Q96KC6, A8K3Q4, A8MTV3, B7Z2G1, D3DX30 |
| UniProt Related Accession: | Q53GT1 |
| Molecular Weight: | 55,567 Da |
| NCBI Full Name: | Kelch-like protein 22 |
| NCBI Synonym Full Names: | kelch like family member 22 |
| NCBI Official Symbol: | KLHL22 |
| NCBI Official Synonym Symbols: | KELCHL |
| NCBI Protein Information: | kelch-like protein 22 |
| UniProt Protein Name: | Kelch-like protein 22 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Kelch-like protein |
| UniProt Gene Name: | KLHL22 |
| UniProt Entry Name: | KLH22_HUMAN |
| Antibodies |
| KLHL22 Antibody (PACO10136) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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