KLHL20 Antibody (PACO10134)
- SKU:
- PACO10134
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | KLHL20 Antibody (PACO10134) |
| Antibody SKU: | PACO10134 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human KLHL20 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | kelch-like 20 (Drosophila);KLHL20;KHLHX;KLEIP;KLHLX;RP3-383J4.3 ; |
| UniProt Protein Function: | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis (PubMed:20389280). The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination (PubMed:24768539). Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking (PubMed:24768539). Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (PubMed:21670212). In case of tumor, the BCR(KLHL20) E3 ubiquitin ligase complex is involved in tumor hypoxia: following hypoxia, the BCR(KLHL20)complex mediates ubiquitination and degradation of PML, potentiating HIF-1 signaling and cancer progression (PubMed:21840486). |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 44-56 amino acid repeat motif. The kelch motif appears in many different polypeptide contexts and contains multiple potential protein-protein contact sites. Members of this family are present both throughout the cell and extracellularly, with diverse activities. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y2M5 |
| NCBI GenInfo Identifier: | 40807500 |
| NCBI Gene ID: | 27252 |
| NCBI Accession: | NP_055273.2 |
| UniProt Secondary Accession: | Q9Y2M5,Q5TZF2, Q5ZF45, Q9H457, B3KMA0, B4DUR0 |
| UniProt Related Accession: | Q9Y2M5 |
| Molecular Weight: | 46,490 Da |
| NCBI Full Name: | kelch-like protein 20 |
| NCBI Synonym Full Names: | kelch like family member 20 |
| NCBI Official Symbol: | KLHL20 |
| NCBI Official Synonym Symbols: | KHLHX; KLEIP; KLHLX |
| NCBI Protein Information: | kelch-like protein 20 |
| UniProt Protein Name: | Kelch-like protein 20 |
| UniProt Synonym Protein Names: | Kelch-like ECT2-interacting protein; Kelch-like protein X |
| Protein Family: | Kelch-like protein |
| UniProt Gene Name: | KLHL20 |
| UniProt Entry Name: |
Related Products
Human TP53 antibody(p53 antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक
SPEF2 Antibody
Overview Product Name:SPEF2 AntibodyProduct Code:PACO64977Size:50µLTarget Names:SPEF2Species Reactivity:HumanHos
ompF Antibody
Overview Product Name:ompF AntibodyProduct Code:PACO64865Size:50µLTarget Names:ompFSpecies Reactivity:Escherichia coli
Hmgb1 Antibody
Overview Product Name:Hmgb1 AntibodyProduct Code:PACO64769Size:50µLTarget Names:Hmgb1Species Reactivity:RatHost