KLHL2 Antibody (PACO27809)
- SKU:
- PACO27809
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | KLHL2 Antibody (PACO27809) |
| Antibody SKU: | PACO27809 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Kelch-like protein 2 protein (1-155AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot Positive WB detected in: Jurkat whole cell lysate, Mouse liver tissue All lanes: KLHL2 antibody at 3µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 66, 67, 57 kDa Observed band size: 66, 67 kDa . |
 | Immunofluorescent analysis of Hela cells using PACO27809 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human liver tissue using PACO27809 at dilution of 1:100. |
| Background: | Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors. |
| Synonyms: | Kelch-like protein 2 (Actin-binding protein Mayven), KLHL2 |
| UniProt Protein Function: | KLHL2: May play a role in organizing the actin cytoskeleton of the brain cells. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 4q21.2 Cellular Component: actin cytoskeleton; cytoplasm Molecular Function:actin binding; protein binding; ubiquitin-protein ligase activity Biological Process: protein ubiquitination |
| UniProt Code: | O95198 |
| NCBI GenInfo Identifier: | 52788227 |
| NCBI Gene ID: | 11275 |
| NCBI Accession: | O95198.2 |
| UniProt Secondary Accession: | O95198,Q8N484, Q8TBH5, A6NCM7, B2RD18, B4DFH7, F5H6M3 |
| UniProt Related Accession: | O95198 |
| Molecular Weight: | 56,086 Da |
| NCBI Full Name: | Kelch-like protein 2 |
| NCBI Synonym Full Names: | kelch like family member 2 |
| NCBI Official Symbol: | KLHL2 |
| NCBI Official Synonym Symbols: | MAV; MAYVEN; ABP-KELCH |
| NCBI Protein Information: | kelch-like protein 2 |
| UniProt Protein Name: | Kelch-like protein 2 |
| UniProt Synonym Protein Names: | Actin-binding protein Mayven |
| Protein Family: | Kelch-like protein |
| UniProt Gene Name: | KLHL2 |
| UniProt Entry Name: | KLHL2_HUMAN |
| Antibodies |
| KLHL2 Antibody (PACO10133) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
