KLHL12 Antibody (PACO10129)

(No reviews yet) Write a Review
SKU:
PACO10129
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Applications:
WB
Applications:
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:KLHL12 Antibody (PACO10129)
Antibody SKU:PACO10129
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human KLHL12
Form:Liquid
Storage Buffer:PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:kelch-like 12 (Drosophila);KLHL12;C3IP1;DKIR;FLJ27152 ;
UniProt Protein Function:KLHL12: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4. Component of the BCR(KLHL12) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL12 and RBX1. This complex interacts with DVL3 upon activation of the Wnt signaling pathway by WNT3A. Interacts with DRD4, KLHL12 and SEC31A. Ubiquitously expressed. Highly expressed in testis and at lower levels in the submandibular salivary gland. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: Golgi membrane; ER to Golgi transport vesicle; cytosol

Molecular Function:protein binding

Biological Process: COPII coating of Golgi vesicle; protein monoubiquitination; ER to Golgi vesicle-mediated transport; Wnt receptor signaling pathway

NCBI Summary:This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation. Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size. A pseudogene has been identified on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
UniProt Code:Q53G59
NCBI GenInfo Identifier:97054498
NCBI Gene ID:59349
NCBI Accession:Q53G59.2
UniProt Related Accession:Q53G59
Molecular Weight:63kDa
NCBI Full Name:Kelch-like protein 12
NCBI Synonym Full Names:kelch like family member 12
NCBI Official Symbol:KLHL12  
NCBI Official Synonym Symbols:DKIR; C3IP1  
NCBI Protein Information:kelch-like protein 12
UniProt Protein Name:Kelch-like protein 12
UniProt Synonym Protein Names:CUL3-interacting protein 1; DKIR homolog; hDKIR
Protein Family:Kelch-like protein
UniProt Gene Name:KLHL12  
UniProt Entry Name:KLH12_HUMAN
View AllClose

0 Reviews

View AllClose

Related Products

SEZ6 Antibody

SEZ6 Antibody

Overview Product Name:SEZ6 AntibodyProduct Code:PACO64941Size:50µLTarget Names:SEZ6Species Reactivity:HumanHost
OR5H6 Antibody

OR5H6 Antibody

Overview Product Name:OR5H6 AntibodyProduct Code:PACO64873Size:50µLTarget Names:OR5H6Species Reactivity:HumanHos